血浆脑钠肽检测在心衰诊断中的临床探讨  

Clinical study of plasma brain natriuretic peptide in the diagnosis of heart failure

作　　者：陈鑫[1] 曹兴华[1] 张志强[1] 

机构地区：[1]漯河市中心医院检验科,河南漯河462000

出　　处：《中国卫生检验杂志》2013年第10期2290-2291,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血浆脑钠肽(BNP)水平对心衰的诊断价值及对心功能评估的意义。方法选该院心衰患者113例为心衰组,健康体检者100名作为对照组,采用锐普荧光干式定量分析仪,荧光免疫法分别测定血浆BNP浓度。依据美国纽约心脏病学会(NYHA)分级方案对心力衰竭患者进行心功能分级。结果 HF组血浆BNP浓度高于对照组(P<0.05)。HF患者中血浆BNP浓度随心功能分级的增加而升高,各组间差异均有统计学意义(P<0.05)。结论血浆BNP是反映心功能的客观指标,对心力衰竭的诊断及心功能评估有重要价值。Objective To investigate the value of plasma brain natriuretic peptide level in diagnosis of heart failure and its significance in assessing cardiac function. Methods One hundred and thirteen patients with heart failure as heart failure group, and 100 healthy persons as control group were selected to determine the plasma BNP level by the rapid fluorescent dry quantitative analyzer and immunofluorescence method. Then the heart failure patients was gra- ded according to the New York Heart Association classification scheme for classification of cardiac function. Results The plasma BNP concentration in HF group was higher than that of the control group （ P 〈 0.05 ）. The plasma BNP concentration increased in patients with HF heart function grade, and the difference between the groups was statistically significant. Conclusion Plasma BNP is an objective index to reflect the cardiac function, having an important significance in diagnosis and cardiac function evaluation of heart failure.

关 键 词：脑钠肽 心力衰竭 心功能分级 

分 类 号：R541.6[医药卫生—心血管疾病]