4001例肿瘤患者血培养标本的结果分析  

Analysis of blood culture specimens from 4001 tumor patients

作　　者：陈华北[1] 毛彩萍[2] 叶珍[2] 崔巍[2] 边佳[2] 

机构地区：[1]杭州市第一人民医院,浙江杭州310006 [2]浙江省肿瘤医院,浙江杭州310006

出　　处：《中国卫生检验杂志》2013年第10期2358-2360,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解肿瘤患者血培养标本的病原菌分布特点和血培养的污染状况及耐药情况。方法对血培养阳性标本采用微生物鉴定仪鉴定,采用WHONET 5.4软件统计和病史查阅并对血培养结果进行回顾性分析。结果 4001份血培养标本中251株菌确认为病原菌,另有10株考虑为污染菌,其中8株为凝固酶阴性葡萄球菌。历年的血培养阳性率在4.84%～8.35%之间,平均阳性率6.27%。251株检出菌包括大肠埃希菌73株(29.08%)、凝固酶阴性葡萄球菌35株(13.94%)、肺炎克雷伯菌33株(13.15%)等;检出菌主要分布在化疗科等,均以革兰阴性菌感染为主。结论肿瘤患者血流感染的病原菌分布范围较广,其中以革兰阴性杆菌感染占主导地位,革兰阳性菌耐药性严重;血培养的污染菌多为凝固酶阴性葡萄球菌。Objective To understand the pathogen distribution, contamination status and drug resistance of blood culture specimens from tumor patients. Methods The blood culture positive specimens were identified by microbi- ology instrument, and the results were analyzed retrospectively by WHONET 5.4 software and the medical history re- view. Results Two hundred and fifty - one pathogenic strains were found from the 401 blood culture samples. An- other 10 isolates were considered as contaminant strains, in which 8 strains were coagulase - negative staphylococci （CNS）. Over the years, the positive rate of blood culture was between 4.84% ~ 8.35% , with the average positive rate of 6.27%. The 251 strains included 73 strains of Escherichia coii（29.08% ）, 35 strains of CNS （ 13.94% ）, 33 strains of Klebsiella pneurnoniae（ 13.15% ）. The positive strains were mainly distributed in the department of chemotherapy, mainly Gram - negative bacteria infection. Conclusion The bloodstream infection pathogens were widely distributed in tumor patients, with grain negative bacillus infection dominant. The drug resistance rate of Gram - positive bacteria were heavier. The contaminant bacteria of blood culture are mainly CNS.

关 键 词：血培养 肿瘤患者 病原菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]