促进肺血管生成发育的细胞因子及信号通路研究进展  

Research progress in cytokines and signaling pathways for promoting pulmonary angiogenesis and vascular development

作　　者：马兴娜[1] 李秋平[1] 封志纯[1] 

机构地区：[1]北京军区总医院附属八一儿童医院新生儿重症监护病房,北京100007

出　　处：《中国当代儿科杂志》2013年第9期800-804,F0003,共6页Chinese Journal of Contemporary Pediatrics

基　　金：国家自然科学基金青年科学基金项目(No.81000265)

摘　　要：随着产前和产后医疗水平和护理水平的提高,支气管肺发育不良(BPD)的发生率逐渐增加,而其发病机制尚不明确,"新型"BPD理论中指出肺泡结构简单化和肺微血管发育异常最终导致肺气血交换的功能减弱是BPD发病的核心机制,因而肺微血管发育的研究逐渐受到重视。肺血管生成及发育过程中需要多种细胞因子及信号通路的参与,这其中最重要的有VEGF/VEG-FR信号通路、Ang/Tie信号通路、Ephrins/Eph信号通路、Notch/Jagged1信号通路等,这些细胞因子及信号通路在肺血管发育过程中发挥重要作用。With the advances in pre- and post-natal medical care, the incidence of bronchopulmonary dysplasia （BPD） is on the rise, while its pathogenesis remains not clear. New BPD theory shows that the core pathogenesis of BPD is simple alveolar structure and pulmonary microvascular abnormalities that eventually lead to reduced pulmonary gas exchange, so the research on pulmonary microvascular development was gradually taken seriously. Pulmonary angiogenesis and vascular development require the participation of various cytokines and signaling pathways, the most important of which include VEGF/VEGFR pathway, Ang/Tie pathway, Ephrins/Eph pathway, and Notch/Jaggedl pathway. These cytokines and signaling pathways play important roles in pulmonary vascular develooment.

关 键 词：肺血管 血管生成 支气管肺发育不良 细胞因子 信号通路 

分 类 号：R722.6[医药卫生—儿科]