共刺激分子OX40在抗感染免疫中的作用  

The role of co-stimulatory molecule OX40 in anti-infection immunity

作　　者：李艳华[1] 丁剑冰[1] 张韬 张耀新 

机构地区：[1]新疆医科大学基础医学院,乌鲁木齐830011 [2]第一附属医院新疆重大疾病医学重点实验室省部共建国家重点实验室培育基地

出　　处：《免疫学杂志》2013年第10期903-906,共4页Immunological Journal

基　　金：国家自然科学基金(81160200,81060135,30860263,81160378)

摘　　要：正性共刺激分子OX40与多种疾病(如肿瘤、自身免疫性疾病、移植排斥反应等)的发生、发展有关,能促进T细胞的活化和细胞因子的分泌。调节性T细胞通过免疫抑制与免疫耐受机制影响疾病的发展。本文主要就OX40/OX40L与调节性T细胞的关联性及其在病毒、细菌、真菌、寄生虫等病原体引起的感染性疾病中的调节机制的研究进展进行简要综述。Positive costimulatory molecule OX40,associated with the generation and development of immunologic diseases（such as tumor,autoimmune diseases,anti-transplantation response）,can enhance the activation and augmentation of cytokines secretion of T cells.Regulatory T cells can influence the development of diseases through the mechanism of immunosuppression and immune tolerance.This review mainly delineates the associativity of OX40 and Treg,as well as the regulatory mechanism of OX40/OX40L on infectious diseases evoked by pathogens such as virus,bacterias,fungus and parasites.

关 键 词：OX40 TREG 感染性疾病 

分 类 号：R392.11[医药卫生—免疫学]