SDF-1/CXCR-4轴在脐血造血干/祖细胞归巢中的作用研究进展  

Progress of the SDF-1 /CXCR-4 axis in the homing of the cord blood hematopoietic stem/progenitor cells

作　　者：杨璐璐[1] 朱小玉[1] 刘欣[1] 

机构地区：[1]安徽医科大学附属省立医院血液内科,合肥230001

出　　处：《新医学》2013年第9期590-593,共4页Journal of New Medicine

基　　金：国家自然科学基金青年基金项目(31101006)

摘　　要：造血干细胞(HSC)移植是有望治愈恶性血液疾病的治疗方法,目前脐血因具有来源丰富、移植物抗宿主病(GVHD)发生率低等优点成为良好的HSC来源,但脐血有限的细胞数量及植入延缓限制了其广泛应用。大量研究表明基质细胞衍生因子及其受体轴(SDF-1/CXCR-4)在造血干/祖细胞归巢中起着重要的作用。该文就SDF-1/CXCR-4轴在脐血造血干/祖细胞归巢中的作用作一介绍。The transplantation of hematopoietic stem cells （HSC） is expected to be the curing treatment of malignant blood diseases. Currently, cord blood has becoming a good source of HSC for its rich source and low incidence of graft-versus-host disease （GVHD） , but a limited number of cord blood cells and implan- tation delay limit its wide application. A large number of studies have shown that stromal cell-derived factor and its receptor play an important role in the homing of hematopoietic stern / progenitor cells （ HSPC ）.

关 键 词：基质细胞衍化因子 CXC趋化因子受体 造血干 祖细胞 归巢 

分 类 号：R55[医药卫生—血液循环系统疾病]