老年2型糖尿病患者血清尿酸与外周动脉疾病的相关性研究  

Association between serum uric acid level and peripheral arterial disease in Chinese elderly patients with Type 2 diabetes

作　　者：梁颖慧[1] 秦明照[1] 陈一文[1] 葛维莹[1] 

机构地区：[1]首都医科大学附属北京同仁医院 干部医疗科,北京100730

出　　处：《中国医刊》2013年第10期23-26,共4页Chinese Journal of Medicine

摘　　要：目的探讨老年2型糖尿病（T2DM）患者血清尿酸（SUA）水平与外周动脉疾病（PAD）的相关性。方法选择338例老年T2DM住院患者，采集病史、人体参数及相关生化指标，测量踝臂指数（ABI）。ABI≤0．90诊断为PAD。比较PAD组和非PAD组的临床资料差异，分析ABI与其他变量的相关性，比较不同尿酸等级的PAD患病率。采用多因素logistic回归分析调整混杂因素检验SUA水平与PAD的关系。结果PAD组的SUA水平及HUA患病率明显高于非PAD组；ABI值与SUA水平负相关；高尿酸血症（HUA）组的PAD患病率高于正常尿酸组；PAD患病率随SUA四分位等级递增而增加，依次为34．9％、35．7％、45．2％、64．5％；多因素logistic回归分析调整混杂因素后，SUA作为连续性自变量时OR值为1．221（95％CI：1．001～1．602）；二分类变量时HUA的OR值为4．457（95％CI：2．221～8．942）；与SUA第一等级比较，第二、三、四等级的OR值分另U为1．246（95％CI：0．603～2．574）、1．391（95％CI：0．678—2．855）、4．203（95％CI：2．019～8．751）。结论SUA水平升高与老年T2DM患者PAD患病密切相关，可能是该人群发生PAD的独立危险因素之一。Objective To investigate the association between serum uric acid （SUA） levels and peripheral arterial dis- ease （PAD） in Chinese elderly patients with Type 2 diabetes （T2DM）. Method A cross-sectional study was conduc- ted among 338 Chinese hospitalized patients with T2DM aged ≥65 years. PAD was diagnosed when the anlde-braehial index（ABI） was ≤0.90. SUA and other well-known risk factors were evaluated between patients with and without PAD. The correlations between ABI and various factors were estimated. Prevalences of PAD were examined in differ- ent categories of SUA levels. Potential confounding variables were adjusted for in multivariate logistic regression analy- sis. Result SUA levels and prevalences of HUA were higher in patients with PAD than in those without PAD. ABIs were inversely related to SUA levels;Prevalences of PAD were higher in patients with HUA than in those with NUA; and prevalences of PAD were increased according to the quartiles of SUA levels, 34.9%, 35.7%, 45.2% and 64.5%, respectively. With SUA level as a continuous variable, the multivariate-adjusted odds ratio （OR） [ 95% confidence interval （CI） ] for PAD was 1. 221; and the multivariate-adjusted OR （95% CI ） for HUA for PAD was 4.457. While compared to quartile 1 of SUA, the multivariate-adjusted OR （95% CI） of quartile 2,3,4 wasl. 246, 1. 391,4.203. Conclusions Elevated SUA level is significantly independent positively associated with PAD in Chinese elderly T2DM patients and may be an independent risk factor for PAD in this population.

关 键 词：外周动脉疾病 踝壁指数 血清尿酸 糖尿病 

分 类 号：R563[医药卫生—呼吸系统]