microRNA在2型糖尿病发生机理中的研究进展  

Advances in Research of MicroRNA in The Pathogenesis of Type 2 Diabetes

作　　者：孙蕾[1] 王勇[1] 杨健[1] 

机构地区：[1]中国医科大学附属盛京医院胆道,疝,减肥外科,辽宁沈阳110004

出　　处：《中国普外基础与临床杂志》2013年第9期1069-1074,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金(项目编号:81000158)~~

摘　　要：目的总结糖尿病及其并发症与microRNA的关系。方法通过检索国内外相关文献,总结microRNA在糖尿病及其并发症发生、发展过程中所起的重要作用。结果 microRNA可以影响胰岛素的分泌,干扰脂肪细胞、肌细胞及肝细胞的糖代谢,使机体产生胰岛素抵抗。同时,microRNA在糖尿病的血管内皮细胞和心肌细胞损伤中也起到了一定作用。结论 microRNA在糖尿病及其并发症的发病过程中均起到了重要作用。Objective To summarize the relationship of diabetes and its complications with microRNA. Methods Domestic and international researches were collected by searching to summarize the role of microRNA in diabetes and its complications. Results MicroRNA could affect the secretion of insulin and interfer metabolism of gulcose in fat cells, muscle cells, and liver cells, which resulting in insulin resistance. At the same time, the microRNA also played an role in damage of vascular endothelial cells and myocardial cell in diabetes. Conclusion MicroRNA acts an important role in the process of diabetes and its complications.

关 键 词：MICRORNA 2型糖尿病 并发症 胰岛素分泌 胰岛素抵抗 肥胖 

分 类 号：R587.1[医药卫生—内分泌]