新型可控降解外科缝合线的研制  

Development of a Novel Controllable Degradable Surgical Suture

作　　者：王佃亮[1] 王瑞玲[2] 

机构地区：[1]第二炮兵总医院药学部,北京100088 [2]第二炮兵总医院消化科,北京100088

出　　处：《生物技术通讯》2013年第5期702-704,共3页Letters in Biotechnology

基　　金：国家自然科学基金(81171201)

摘　　要：目的:研制一种新型的可控降解手术缝合线,以满足不同伤口缝合的需要。方法:缝合线的最里层为壳聚糖纤维芯,中间为胶原层,最外层为羧甲基壳聚糖层;从里到外,各层厚度比例为2∶x∶(3-x),其中1<x<3。结果:不同型号的缝合线降解速度可控,适用于不同愈合期的伤口缝合,并具有很好的生物相容性和抗感染性。结论:研制的新型缝合线操作方便,性价比高,植入体内后降解速度可控,伤口愈合快,不留明显疤痕,尤其适于野战环境条件下应用。Objective： To develop a novel controllable degradable suture for suturing different wounds. Methods： It＇s chitosan fiber, collagen layer and carboxymethyl chitosan layer from inside to outside of the sure in turn, and correspondingly the thickness ratio is 2：x： （3-x）, 1〈x〈3. Results： As the degradation rates of different sutures are controllable, different sutures that have good bioeompatibility and are anti-infectious are suitable for suturing different healing wounds. Conclusion： The novel suture which operation is simple and convenient is relatively cheap, controllable degradation, rapid wound healing, no obvious scar, and especially for field environment application.

关 键 词：外科缝合线 可控降解 抗感染 生物相容性 野战环境 

分 类 号：R318[医药卫生—生物医学工程]