取代苯氧基-3-乙酰吡啶类中间体的合成  

Synthesis of substituted phenoxy-3-acetylpyridine intermediates

作　　者：万川[1] 韩小强[1] 周子原[1] 贾长青[1] 杜士杰[1] 杨冬燕[1] 覃兆海[1] 

机构地区：[1]中国农业大学理学院,北京100193

出　　处：《化学试剂》2013年第10期871-873,共3页Chemical Reagents

基　　金：国家"十二五"科技支撑计划资助项目(2012-BAK25B03)

摘　　要：由6-氯烟酸出发经两步合成了16个苯氧基-3-乙酰吡啶类中间体,其中14个为新化合物。通过改变缚酸剂缩短了反应时间,提高了收率,与现有文献报道的合成方法相比,具有步骤少、反应时间短、收率高的优点。产物结构经核磁、质谱表征得到确认。16 Different phenoxy-3-acetylpyridine intermediates was synthesized by two steps starting from 6-ehloronicotinic acid, 14 of which are new compounds. This method can short- en the reaction time and improve the yield by changing the acid-binding agent. Compared with literature methods, this method has the advantages of shorter steps and reaction time, and high yield. The structure of the products were confirmed by 1HNMR,MS.

关 键 词：二芳醚 吡啶衍生物 合成 

分 类 号：O626.32[理学—有机化学]