蒎酮酰基硫脲衍生物的合成及杀虫活性研究  

Synthesis and insecticidal activity of acylthiourea derivatives of pinonic acid

作　　者：尹延柏 韩嘉 张雅莉 刘涛 宋湛谦 

机构地区：[1]济宁市产品质量监督检验所,山东济宁272100 [2]兖矿国宏化工有限公司,山东邹城373500 [3]鲁南煤化工研究院,山东济宁272100 [4]中国林业科学研究院林产化学工业研究所,江苏南京210042

出　　处：《化学试剂》2013年第10期929-932,共4页Chemical Reagents

基　　金：国家质检总局科技计划资助项目(2012QK242);山东省质监局科研资助项目(2012KYZ32)

摘　　要：以蒎酮酸为原料,经酰氯化、亲核取代、亲核加成等反应,与取代苯胺生成了7个含四元环结构的酰基硫脲衍生物,其中6个为首次合成。所合成的产品经IR、1HNMR进行了结构鉴定。研究了所合成化合物对亚洲玉米螟的杀虫活性,该类化合物对亚洲玉米螟表现出一定的杀虫活性,并表现出一定的构效关系。Seven acylthioureas derivatives containing a cy- clobuane ring were synthesized via acylchlorination, nucleo- philic substitution and nucleophiIic addition reaction using pi- nonic acid and substituted aniline as raw materials and six of which were obtained firstly. The structures were confirmed by IR and 1HNMR. The insecticidal activity of the synthetic de- rivatives against Ostrinia furnacalis was invesitigated. The re- suits indicated that synthetic derivatives showed certain insec- ticidal activity against Ostrinia furnacalis. Moreover a close relationship between their structure and effect was estab- lished.

关 键 词：酰基硫脲 蒎酮酸 杀虫活性 

分 类 号：O624[理学—有机化学]