含肟醚的新型噻二唑类化合物的合成及表征  

Synthesis and characterization of novel 1,3,4-thiadiazoles containing oxime ether moiety

作　　者：曹宇[1] 黄讲[1] 黄振宇[1] 杨小洪[1] 

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000

出　　处：《化学试剂》2013年第10期951-953,共3页Chemical Reagents

基　　金：湖北省教育厅重点项目(D20111902);湖北省高校校企合作资助项目(XD20100686);湖北民族学院团队项目(MY2011T004)

摘　　要：氯乙酸与氨基硫脲反应合成了2-氨基-5-氯甲基-1,3,4-噻二唑,芳香醛与羟胺反应合成了取代苯基甲酮肟,2-氨基-5-氯甲基-1,3,4-噻二唑与取代苯基甲酮肟反应得到6个未见文献报道的目标化合物肟醚。经元素分析、IR和1HNMR进行了结构确认。Chloroactic acid was reacted with thiosemicarbazide to yield 5-chloromethyl-[ 1,3,4 ] thiadiazol-2-ylamine. At the same,different aldehydes was reacted with hydroxylamine to yield the substituted benzoyl oxime. The title compounds were obtained by the reaction of 2-chloromethyl-5-amino-1,3,4-th- iadiazole with substituted benzoyl oxime. All the compounds were characterized by the physical constants, elementary anal- ysis, IR, and l HNMR.

关 键 词：肟醚 噻二唑 合成 

分 类 号：O626[理学—有机化学]