单唾液酸四己糖神经节苷脂钠治疗新生儿缺氧缺血性脑病的临床疗效  

Clinical Effects of Monosialotetrahexosyl Ganglioside on Neonates with Hypoxic-ischemic Encephalopathy

作　　者：梁晓华 

机构地区：[1]广东省罗定市人民医院,广东罗定527200

出　　处：《中国医药指南》2013年第26期16-17,共2页Guide of China Medicine

摘　　要：目的探讨运用单唾液酸四已糖神经节苷脂钠治疗新生儿缺氧缺血性脑病的临床疗效。方法将64例缺氧缺血性脑病患儿随机分成治疗组32例和对照组32例,对照组在常规治疗基础上用脑蛋白水解物治疗,治疗组在常规治疗基础上用单唾液酸四己糖神经节苷脂钠治疗。观察两组的疗效、头颅CT变化、患儿神经行为的影响。结果治疗组临床症状体征的恢复、CT恢复正常率及新生儿行为神经评分均优于对照组,两组差异有统计学意义(P<0.05)。结论神经节苷脂治疗新生儿缺氧缺血性脑病可明显改善症状,促进神经损伤的恢复,提高患儿生存质量,降低病死率和伤残率。Objective To explore the use of monosialotetrahexosyl ganglioside sodium in the treatment of neonates wit hypoxic-ischemic encephalopathy clinical curative effect. Methods Sixty-four neonates with hypoxic-ischemic encephalopathy were randomLy divided into the treatment group and the control group. The control group was treated with conventional way combined with brain protein hydrolysate, and the treatment group was treated with conventional way combined with monosialotetrahexosyl ganglioside sodium intravenous drip （20 mg per day） for 10-14 days. Effects were observed, CT changes, neurobehavioral effects in children. Results Recovery, CT treatment group, clinical symptoms and signs of recovery rate and neonatal behavioral neurological scores were better than the control group, there was significant difference between two groups （P〈0.05）. Conclusion Monosialotetrahexosyl ganglioside treatment of neonatal hypoxic ischemic encephalopathy may improve symptoms, promote nerve regeneration, increasing the survival quality, and reduce the mortality and disability rate.

关 键 词：新生儿 缺氧缺血性脑病 神经节苷脂 新生儿行为神经评分 临床疗效 

分 类 号：R725[医药卫生—儿科]