不同剂量PDE5抑制剂治疗男性勃起功能障碍的疗效研究  

Clinical research of different doses of PDE5 inhibitors used in male erectile dysfunction

作　　者：叶雪挺[1] 陈洪德[1] 张奕荣[1] 

机构地区：[1]温州医科大学附属第一医院泌尿外科,浙江温州325000

出　　处：《中国现代医生》2013年第29期50-52,共3页China Modern Doctor

基　　金：浙江省温州市科技计划项目(Y20110182)

摘　　要：目的观察不同剂量磷酸二酯酶(PDE5)抑制剂治疗男性勃起功能障碍的疗效。方法 ED患者随机分为A、B、C三组,每次分别给予5 mg、10 mg和20 mg不同剂量伐地那非口服。结果三组患者治疗后国际勃起功能指数(IIEF)均高于治疗前(P<0.05)。A、B、C三组患者日记记录插入成功率分别为72.0%、76.0%、68.0%;完成性交的成功率分别为60.0%、72.0%、64.0%,均高于治疗前(P<0.05)。A、B、C组药物副反应发生率分别为28.0%、32.0%、64.0%,C组明显低于A、B两组(P<0.05)。结论伐地那非给药5 mg/次即有治疗ED的效果,且药物副作用低。Objective To observe the clinical effect of different doses of PDE5 inhibitors for treatment of male erectile dysfunction. Methods Patients with erectile dysfunction were divided into A, B and C group, respectively given oral vardenafil 5 rag/time, 10 rag/time, 20 mg/time for three months. Results After the treatment,the IIEF of all groups was significantly higher than before （P 〈 0.05）. Sexual intercourse success rates of A, B and C groups which were recorded in diary were 72.0%, 76.0% and 68.0% respectively. And the success rates of intercourse were 60.0%, 72.0% and 64.0%. They were significantly higher than before treatment （P 〈 0.05）. The rate of drug side effects of group A, B and C were 28.0%, 32.0%and 28.0% respectively. Compared with group A and B, C group had difference which was sta- tistically significant （P 〈 0.05）. Conclusion Dose of 5 mg/time of vardenafil is effective for the treatment of ED with fewer drug side effects.

关 键 词：磷酸二酯酶抑制剂 男性勃起功能障碍 疗效 副反应 

分 类 号：R698.1[医药卫生—泌尿科学]