肠外营养导致新生儿相关性胆汁淤积的高危因素分析  

High-risk factor analysis of parenteral nutrition associated cholestasis in neonates

作　　者：王晓亮[1] 

机构地区：[1]山东省烟台毓璜顶医院儿内科,山东烟台264000

出　　处：《中国当代医药》2013年第29期175-176,共2页China Modern Medicine

摘　　要：目的探讨肠外营养导致新生儿相关性胆汁淤积(PNAC)的高危因素。方法选择本院收治的肠外营养(PN)新生儿150例,将发生PNAC的新生儿设为观察组,共45例,PNAC发生率为30.0%,另外105例设为对照组,对比分析两组相关指标,探讨发生PNAC的高危因素。结果观察组的胎龄、出生体重、PN持续时间、感染率与对照组比较,差异有统计学意义(P<0.05);变量逐个引入Logistic回归模型进行多因素分析,PN持续时间是PNAC的独立高危因素,胎龄是其保护因素。结论 PN持续时间是新生儿发生PNAC的主要原因,尽量减少PN持续时间是保证新生儿PNAC低发生率的重要措施,胎龄是PNAC发生的保护因素。Objective To investigate the high-risk factors of parenteral nutrition associated cholestasis （PNAC）in neonates.Methods 150 neonates who had received parenteral nutrition （PN）in our hospital were selected,of which 45 neonates having PNAC were assigned to the observation group,accounting for 30.0%,and the other 105 neonates were assigned to the control group.The related indicators of the two groups were analyzed comparatively and the high-risk factors of PNAC were explored.Results The gestational age,birth weight,PN duration and infection of the observation group were compared with those of the control group,there were statistical difference （P〈0.05）;the multivariate analysis was conducted through introducing the variables one by one into the Logistic regression model,which found that PN duration was an independent high-risk factor for PNAC and the gestational age was a protective factor.Conclusion PN duration is a major cause of neonatal PNAC and therefore the reduction of PN duration is an important measure to guarantee the low incidence of neonatal PNAC,the gestational age was a protective factor.

关 键 词：肠外营养 新生儿 胆汁淤积 高危因素 

分 类 号：R726[医药卫生—儿科]