米非司酮治疗过期流产200例疗效观察  

Effect observation of mifepristone in the treatment of missed abortion:200 cases

作　　者：孙春旺[1] 卢倩文[1] 

机构地区：[1]中山大学附属第五医院,广东省珠海市519000

出　　处：《临床合理用药杂志》2013年第26期26-27,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察米非司酮在治疗过期流产中的治疗效果。方法 200例过期流产患者,随机分为观察组和对照组,每组各100例。观察组采用先服用米非司酮配伍米索前列醇,后行清宫术进行治疗;对照组采用己烯雌酚联合清宫术进行治疗,对2组的临床疗效进行观察,对2组患者宫口松弛度、出血量、胚胎娩出时间进行比较分析。结果观察组临床治疗效果显著优于对照组,观察组患者术中出血量、胚胎娩出时间、二次清宫、宫口松弛度适合情况均显著优于对照组,2组比较差异有统计学意义(P<0.05)。结论服用米非司酮对过期流产患者进行治疗,能使患者宫口松弛度得到提高,减少术中出血量,使胚胎更容易脱落,且胚胎娩出时间短,患者痛苦小,值得临床推广应用。Objective To observe the effect of mifepristone in the treatment of missed abortion. Methods 200 cases of missed abortion patients were randomly divided into observation group and control group, each of 100 cases. The observation group was given mifepristone with misoprostol, and then received curettage for treatment;the control group was given diethylstilbestrol and curettage for treatment. The clinical efficacy of 2 groups was observed. The cervix laxity, amount of bleeding and embryo disengagement time of 2 groups were compared and analyzed. Results The clinical effect of the observation group was significantly better than that of the control group, and the cervix laxity, amount of bleeding and embryo disengagement time of the observation group were all better than those of the control group, and the difference was statistically significant （ P 〈 0. 05）. Conclusion Treating missed abortion with mifepristone,which can improve the laxity cervix degree of patients, reduce blood loss ,the embryo is more easy to fall off, and the embryo disengagement time is more shorter, so it is worthy of clinical application .

关 键 词：米非司酮 过期流产 疗效观察 

分 类 号：R714.21[医药卫生—妇产科学]