干扰素用于重组乙肝疫苗的佐剂作用  

Interferon as An Adjuvant of Recombinant Hepatitis B Vaccine

作　　者：罗璇[1] 魏自力[1] 陈万革[1] 蔡岩[1] 刘大维[1] 韩立卓[2] 

机构地区：[1]长春生物制品研究所,长春130062 [2]吉林省人民医院,长春130021

出　　处：《中国生物制品学杂志》2000年第4期229-231,共3页Chinese Journal of Biologicals

摘　　要：目的　为了提高乙肝疫苗的免疫原性。方法　在重组乙肝疫苗中加入不同单位的干扰素构成复合佐剂 ,通过小鼠腹腔和肌肉两种免疫途径 ,对疫苗的体液免疫和细胞免疫进行了检测。结果　干扰素作为复合铝佐剂 ,无论是对体液免疫还是细胞免疫 ,效果均较对照明显提高。结论　不同亚型的IFN作为乙肝疫苗佐剂 ,均可提高疫苗的免疫原性。Objective To improve the immuogenicity of hepatitis B vaccine.Methods Mice were immunized with the hepatitis B vaccine using interferon and Al(OH) 3 complex adjuvant,and the humoral and cell immune responses of them were studied.Results Both humoral and cell immunity of the vaccine using complex adjuvant were significantly higher than that using Al(OH) 3 adjuvant alone.Conclusion Interferon can be used as an adjuvant of hapatitis B vaccine.

关 键 词：佐剂 体液免疫 细胞免疫 干扰素 重组乙肝疫苗 

分 类 号：R512.620.3[医药卫生—内科学]