IFN-α治疗慢性乙肝抗病毒疗效与细胞因子变化关系分析  

A Study on the Relation between Changes of Interleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN-α

作　　者：何生松[1] 李淑莉[1] 熊莉娟[1] 刘薇[1] 曾令兰[1] 

机构地区：[1]同济医科大学附属协和医院传染科,武汉430022

出　　处：《中国病毒学》2000年第4期342-345,共4页Virologica Sinica

基　　金：教育部回国人员科研启动基金![教外司;留学生 1997(4 36 ) ];深圳科兴公司资助

摘　　要：观察慢性乙型病毒性肝炎 (CHB)患者 ( 2 5例 )经α 干扰素 (IFN α)抗病毒治疗前后血清中细胞因子和受体水平的变化与乙肝病毒消长之间的关系。收集治疗前后血清标本ELISA法同步检测 ,根据治疗后乙肝病毒复制指标 (HBV DNA)阴转分应答组 ( 10例 )与无应答组 ( 15例 )进行统计学分析。治疗后两组血清中IL 6水平下降 ,尤其应答组下降明显 ;治疗后应答组IL 2水平明显升高 (P <0 .0 1) ,sIL 2R水平则明显下降 ;但治疗后两组TNF α均较治疗前下降 ,相反IL 8水平升高接近正常人水平 ;CHB患者体内存在免疫功能的失调 ,通过IFN α免疫调节 (IL 6、IL 2、sIL 2R)对病毒复制影响具有重要作用。但TNF α和ILObjective\ To study the relationship between the changes of Interleukin and Receptor in serum of patients with chronic hepatitis B (CHB) before and after Interferon α (IFN α) treatment and expression of HBV marker. Methods: Enzyme liked immunosorbent assay (ELISA) were performed in 25 patients with CHB to determine levels of IL 6\, IL 2\,TNF α\, IL 8\, sIL 2R in serum. Results: Our date showed that the IL 6 level in response group after IFN α treatment was significantly lower than that befor (P<0.05). The level of IL 2 in unresponse group after IFN α treatment was significantly decreased, but the level in response group was significantly increased (P<0.01), but the serum sIL 2R level in patients with response was significantly decreased (P<0.01). The TNF α level in both response and unresponse group after IFN α treatment was significantly decreased (P<0.01), but the serum IL 8 level was increased. Conclusion\ The results suggest that HBV replication in patients with CHB could be also affected by immunoregulation of IFN α for IL 6\,IL 2\,sIL 2R, but HBV replication could be not affected by TNF α and IL 8 levels in serum.

关 键 词：慢性乙型病毒性肝炎 白细胞介素 Α-干扰素 

分 类 号：R373[医药卫生—病原生物学]