实验性肾功能衰竭大鼠血浆中分子物质总量和自由基的变化研究  

Study on the variance of level of plasma middle molecule substance and free radical in rats with experimental chronic renal failure

作　　者：许涛[1] 钱琛[1] 汪远金[1] 

机构地区：[1]安徽中医学院中西医结合系,合肥230038

出　　处：《生物学杂志》2000年第6期24-24,23,共2页Journal of Biology

摘　　要：用腺嘌呤复制动物性慢性肾功能衰竭 (CRF)模型。观察大鼠血浆血尿素氮 (BuN)、血肌酐 (Cr)、血红蛋白 (Hb)、超氧化物歧化酶 (SOD)和中分子物质 (MMS)总量的变化。结果表明 ,CRF大鼠血浆BuN、Cr和MMS总量明星升高 (P <0 0 1 )、Hb和SOD含量显著降低 (P <0 0 1 )。提示CRF大鼠MMS总量升高、SOD活性降低。Objective To observe the variance of the sum of hBun,hCr,hHb,hSOD and hMMS(middle molecule substance)in plasma of rats with experimental chronic renal failure.Methods Re-making animal model with adenine in rats with experimental chronic renal failure(CRF).Results The sum of hBun,hCr,and hMMS in plasma of rats with experimental CRF is apparently increased(P<0.01),and that of hHb and hSOD is apparently decreased(p<0.01).Conclude The results indicated that the content of hMMS was apparently increased and the SOD activity was decreased,compared with the normal group.

关 键 词：中分子物质血红蛋白 肾功能衰竭 自由基 血浆 

分 类 号：R692.5[医药卫生—泌尿科学]