盐酸二甲双胍的表面增强拉曼光谱研究  

Study of Metformin Hydrochloride by Surface Enhanced Raman Scattering

作　　者：范蕾 张雁[2,3] 尹利辉[2] 

机构地区：[1]湖南省食品药品检验研究院,长沙410000 [2]中国食品药品检定研究院 [3]湖南省湘潭市食品药品检验所

出　　处：《中国药师》2013年第9期1319-1321,共3页China Pharmacist

基　　金："重大新药创制"科技重大专项(编号:2011ZX09303-001)

摘　　要：目的:研究盐酸二甲双胍在不同激发光波长下的固体拉曼光谱以及不同酸碱度条件下的表面增强拉曼光谱,对比固体谱,分析盐酸二甲双胍表面增强拉曼光谱中的分子振动模式。方法:用2种不同的激发光波长对盐酸二甲双胍固体粉末及不同pH条件下盐酸二甲双胍溶液的表面增强拉曼散射(SERS)进行考察。结果:体系的pH对盐酸二甲双胍的增强效应有较大的影响,在碱性条件下,盐酸二甲双胍的SERS效应最强,而其他两种pH条件下均不明显。另外,激发光波长对盐酸二甲双胍的SERS效应也有较大影响。结论:本方法简单、快速、专属性强,可以作为分析盐酸二甲双胍分子结构信息的方法。Objective： To study the Raman spectrum and the surface enhanced Raman scattering （SERS） of metformin hydrochlo- ride under the acidic/basic conditions with various optical luminescences to identify the pattern of molecule vibration compared with the solid spectrum. Method： Two kinds of excitation wavelengths were adopted in the study of Raman spectrum and SERS of metformin hydrochloride under the different pH conditions. Result： The pH value of the system had obvious effect on SERS, under the basic con ditions, SERS of metformin hydrochloride was the strongest, while that was not obvious under the other two pH conditions. In addition, the optical fuminescences also had notable effect on SERS. Conclusion： The method is reliable, rapid and specific, and can be used to analyze the molecular structure of metformin hydrochloride.

关 键 词：盐酸二甲双胍 表面增强拉曼光谱 分子振动模式 PH 分子结构 

分 类 号：R917[医药卫生—药物分析学]