糖尿病大鼠HDL-C和LDL-C的变化及丝胶的调节作用  

CHANGES OF HDL-C AND LDL-C OF DIABETIC RATS AND REGULATORY EFFECTS OF SERICIN

作　　者：杨振军[1] 张艳[1] 侯丽娜[1] 刘东慧[1] 陈志宏[1] 

机构地区：[1]承德医学院人体解剖学教研室,河北承德067000

出　　处：《承德医学院学报》2013年第5期372-374,共3页Journal of Chengde Medical University

基　　金：河北省自然科学基金项目(H2012406018;H2013406096)

摘　　要：目的:探讨丝胶对2型糖尿病大鼠低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)的调节作用。方法:48只雄性SD大鼠随机分为正常对照组、糖尿病模型组、丝胶治疗组和阳性对照组,每组12只大鼠。25mg/kg链脲佐菌素腹腔注射3d(1次/d)建立2型糖尿病大鼠模型;模型成功建立后,糖尿病模型组大鼠不再做任何处理,丝胶治疗组大鼠给予丝胶(2.4g/kg/d)灌胃35d,阳性对照组大鼠给予二甲双胍(55.3mg/kg/d)灌胃35d。分别检测各组大鼠的血糖以及血清HLD-C和LDL-C的水平。结果:与正常对照组大鼠比较,模型组大鼠的血糖、LDL-C明显升高,HDL-C明显降低(P<0.01,P<0.05);与模型组大鼠比较,丝胶治疗组、阳性对照组大鼠的血糖、LDL-C明显降低,HDL-C明显升高(P<0.01)。结论:丝胶可通过提高HDL-C水平、降低LDL-C水平改善糖尿病时血脂代谢紊乱。Objective：To investigate the regulatory effects of sericin on low density lipopmtein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） of type 2 diabetic rats.Methods： 48 male SD rats were randomly divided into normal control group, diabetes model group, sericin treatment group and positive control group （n=12）. Streptozotocin （25mg/kg） was injected into the peritoneal cavity for 3 days （one time a day） to establish type 2 diabetes rats model. Then the rats in model group received no more treatments; the rats in sericin treatment group were lavaged sericin （2.4g/kg/d） for 35-day＇, the rats in positive control group were lavaged metfomin （55.3mg/kg/d） for 35-day. The blood glucose, HDL-C and LDL-C of rats in each group were respectively detected.Results：Compared with rats in normal control group, the blood glucose and LDL-C of rats in model group increased obviously, while HDL-C decreased obviously （P〈 0.01,P〈 0.05）. Compared with rats in model group, the blood glucose and LDL-C of rats in sericin treatment group and positive control group decreased significantly, while HDL-C increased significantly （P〈 0.01 ）. Conclusions： Sericin can obviously improvelipid disorder ofdiabetes mellitus by increasing HDL-C and decreasing LDL-C.

关 键 词：2型糖尿病 血脂 HDL-C LDL-C 丝胶 

分 类 号：R587.1[医药卫生—内分泌]