常州地区疑难输血患者不规则抗体分析  

Analysis of irregular RBC antibodies in 231 patients from Changzhou

作　　者：闵志军[1] 张建伟[1] 曹伟春[1] 徐立[1] 许飞[1] 

机构地区：[1]常州市中心血站,江苏常州213014

出　　处：《临床血液学杂志（输血与检验）》2013年第5期711-712,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:分析常州地区患者中不规则抗体检出情况。方法:对2011-05-2012-11常州地区各医院送检的疑难配血标本231例,应用盐水、抗球蛋白法、凝聚胺法检测不规则抗体。结果:共确认血型不规则抗体54例。其中自身抗体13例(高效价冷凝集素9例;未知的特异性自身IgG型抗体4例),药物引起的抗体2例,同种特异性抗体39例,分别为:抗-E 15例(1例为IgM型)、抗-M 13例、抗-E伴抗-c 1例、抗-C伴抗-e 1例、抗-D 8例(1例为IgM型)、抗-Leb 1例。结论:检出的不规则抗体与文献报道有较大差异,抗-M检出率较高,Rh系统抗体差别不大。Objective： To estimate the frequency and specificity of clinically significant irregular RBC antibodies in hospitalized patients in Changzhou. Method： A total of 231 blood samples were collected from hospitals in Chang zhou, Modified polybrene test and conventional serologic methods were used for the identification of antibody specificity. Result：Clinically significant irregular antibodies were found in 54 patients. Thirteen samples were autoanti- bodies（excluding cold autoantibodies 9, unconfirmed IgG antibodies 4）, and 2 samples were drug antibodies,others were alloantibodies. The qualities of alloantibodies found among patients were： anti-D 8 （excluding IgM 1）, anti E 15 （excluding IgM 1 ）,anti-cE 1 ,anti-Ce 1 ,anti-M 13 ,anti Leb 1. Conclusion： Our data showed significant difference compared with Caucasian data. We had found more anti-M in Changzhou area,and there was no difference between Changzhou and other area in Rh system antibodies.

关 键 词：血型 不规则抗体 频率 

分 类 号：R457.1[医药卫生—治疗学]