2011-2012年南京地区无偿献血人群丙型肝炎病毒感染情况分析  

Prevalence of hepatitis C virus infections among voluntary blood donors in Nanjing

作　　者：朱绍汶[1] 陈显[1] 王金花[1] 王跃帮[1] 林红[1] 

机构地区：[1]江苏省血液中心,南京210042

出　　处：《临床血液学杂志（输血与检验）》2013年第5期718-720,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

基　　金：江苏省卫生厅科技项目(No:H201225);江苏省预防医学会科技项目(No:Y2012002)

摘　　要：目的:了解南京地区无偿献血人群丙型肝炎病毒(HCV)感染情况。方法:收集2011-2012年129328份无偿献血者的血液标本进行ELISA双试剂抗-HCV检测以及混样核酸检测,并对其结果进行统计分析。结果:2011-2012年南京地区无偿献血者的抗-HCV阳性率为0.25%(327/129 238),HCV RNA阳性率为0.10%(130/129 238)。丙肝病毒的感染与性别和受教育程度不相关(P>0.05),但与献血者的年龄、职业密切相关(P<0.05);同时抗-HCV阳性率与ALT、HCV RNA之间具有一定的相关性,但与乙肝病毒、艾滋病病毒和梅毒感染无关。结论:南京地区无偿献血人群中抗-HCV阳性率较低,且主要为单纯性感染。Objective：To investigate the prevalences of anti-HCV and HCV RNA among volunteer blood do nors in Nanjing. Method： A total of 129 328 blood samples from volunteer blood donors were recruited from January 2011 to December 2012 in Jiangsu. The anti-HCV assays were performed by ELISA with reagents from two different manufactures and HCV RNA were detected by nucleic acid amplification test with Roche combas s 201. The re suits were analyzed statistically. Result： Anti HCV positive rate among volunteer blood donors in Jiangsu was 0.25%（327/129328）. HCV RNA positive rate was 0.10%（130/129 328）. There was statistical significance in different ages and occupations and no significance in gender and education level. Conclusion：The anti HCV prevalence is relatively low among volunteer blood donors and HCV infection is mainly simple infection in Nanjing.

关 键 词：无偿献血者 丙型肝炎病毒 血清学筛查 核酸检测 

分 类 号：R512.6[医药卫生—内科学]