盐酸氨溴索在上呼吸道感染患儿手术全身麻醉中的应用  

Value of ambroxol in general anesthesia of children with upper respiratory tract infections

作　　者：刘晓欧[1] 黄光伟[1] 干诚[1] 

机构地区：[1]遵义市妇幼保健院麻醉科,贵州遵义563000

出　　处：《中华医院感染学杂志》2013年第19期4737-4739,共3页Chinese Journal of Nosocomiology

基　　金：遵义市科技局资助项目(遵市科合社字[2012]40)

摘　　要：目的探讨盐酸氨溴索在上呼吸道感染小儿全身麻醉中的应用价值,为减少小儿上呼吸道感染进行全身麻醉的并发症提供理论依据。方法选择100例伴有上呼吸感染全身麻醉的患儿为研究对象,将其随机分为观察组和对照组各50例,对照组给予常规的全身麻醉,观察组在麻醉前给予气管内注入盐酸氨溴索,观察两组患儿呼吸道并发症的发生。结果麻醉后30、60min和术毕的心率对照组分别为(123.5±11.7)次/min、(126.8±11.8)次/min和(113.8±11.4)次/min,观察组分别为(113.6±10.6)次/min、(114.6±11.5)次/min、(104.6±11.6)次/min,两组差异有统计学意义(P<0.05);患儿肺部呼吸音清晰的阳性率观察组为94.00%,对照组为66.00%,两组差异有统计学意义(P<0.01);呛咳发生率观察组为12.00%,对照组为32.00%,两组差异有统计学意义(P<0.05)。结论盐酸氨溴索在上呼吸道感染小儿全身麻醉中应用,能明显减少呼吸道并发症,值得临床推广应用。OBJECTIVE To explore the application value of ambroxol in general anesthesia of the children with upper respiratory tract infections so as to reduce the incidence of complications in the children undergoing general anesthesia. METHODS A total of 100 children with upper respiratory tract infections who underwent the general anesthesia were enrolled in the study and randomly divided into the observation group and the control group, with 50 cases in each, then the control group was treated with the conventional general anesthesia, the observation group was treated with intratracheal injection of ambroxol, and the incidence of respiratory tract complications was observed. RESULTS The heart rate at 30 rain after the anesthesia was（123. 5±11. 7） times/min in the control group, （113.6± 10. 6） times/rain in the observation group ; the heart rate at 60 min after the anesthesia was （126.8± 11. 8）times/min in the control group, （114. 6 ]±11. 5）times/min in the observation group; the postoperative heat rate was （113. 8 ±11.4）times/rain in the control group , （104. 6 ±11. 6）times/rain in the observation group, the difference between the two groups was significant （P〈 0. 05）. The incidence of clear pulmonary respiration was 94.00% in the observation group, 66.00~ in the control group, the difference between the two groups was significant（P^0.01 ） ; the incidence of cough was 12.0~ in the observation group, 32.00~ in the control group, the difference between the two groups was significant（P〈0.05）. CONCLUSION The use of ambroxol for the general anesthesia of the children with upper respiratory tract infections can significantly reduce the incidence of respiratory tract complications, it is worthy of clinical application.

关 键 词：盐酸氨溴索 全身麻醉 上呼吸道感染 手术 

分 类 号：R181.32[医药卫生—流行病学]