2011年ICU与非ICU病原菌耐药监测  

Surveillance of drug resistance of pathogens from ICU and non-ICU wards in 2011

作　　者：王晶[1] 肖晓光[1] 韩丽霞[1] 万献尧[1] 

机构地区：[1]大连医科大学附属第一医院检验科,辽宁大连116011

出　　处：《中华医院感染学杂志》2013年第19期4806-4808,共3页Chinese Journal of Nosocomiology

基　　金：辽宁省自然科学基金(201102053)

摘　　要：目的了解重症监护病房(ICU)与非ICU常见病原菌分布,对常见病原菌的耐药性进行比较,为不同病区经验性使用抗菌药物提供实验室依据。方法用Microscan96微生物鉴定和药敏系统对细菌进行鉴定和药敏试验,部分药敏采用K-B纸片扩散法进行药敏试验,用WHONET5.4软件进行数据分析。结果 ICU排在前4位的病原菌为鲍氏不动杆菌、铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌,分别占24.4%、19.4%、17.4%、11.2%;非ICU排在前4位的病原菌为肺炎克雷伯菌、大肠埃希菌、铜绿假单胞菌、鲍氏不动杆菌,分别占21.0%、17.6%、13.6%、13.3%;ICU常见病原菌的耐药率均明显高于非ICU。结论 ICU以非发酵革兰阴性杆菌为主.且耐药程度明显高于非ICU,非ICU的菌种分布以肠杆菌科细菌为主,对不同病房应该单独进行细菌耐药性监测。OBJECTIVE The investigate the distribution of common species of pathogens in ICU and non-ICU wards and compare the drug resistance so as to provide laboratory basis for the empirical use of antibiotics. METHODS The identification of bacteria isolated and sensitivity tests were checked by Microscan96 system. Some antibiotic sensitivity tests were measured by K-B method. WHONEITS. 4 software was used to analyze data. RESULTS The top four organisms isolated in ICU wards were Acinetobacter baumanii （24. 4%）, Pseudomonas aeruginosa （19.4%） ,Klebsiella pneumoniae （17.4%）, Staphylococcus aureus （11. 2%）. In non-ICU wards, the top four organisms were K. pneumoniae （21. 0%）, Escherichia coli （17. 6%）, P. aeruginosa （13.6 % ）, A. baumanii （13.3%）. The antibiotic resistance rates of the clinical isolates from ICU wards were much higher than those in non-ICU wards. CONCLUSION Non-fermenting gram-negative bacilli are the main isolates in ICU wards and have significantly higher antibiotic resistance rates than those in non-ICU ward. So the antibiotic resistance rates in different wards should be monitored alone.

关 键 词：重症监护病房 耐药率 革兰阴性杆菌 

分 类 号：R378[医药卫生—病原生物学]