氯己定洗浴预防ICU中心静脉导管相关性血流感染效果的荟萃分析  

Meta-analysis of effect of chlorhexidine bathing on prevention of central venous catheter-related bloodstream infections in ICU

作　　者：吴晓琴[1] 郭晶[2] 李琳[1] 苏霞[3] 

机构地区：[1]徐州医学院第二附属医院感染管理科,江苏徐州221006 [2]浙江医学高等专科学校,浙江杭州310053 [3]吉林大学护理学院,吉林长春130012

出　　处：《中华医院感染学杂志》2013年第20期4894-4896,共3页Chinese Journal of Nosocomiology

基　　金：徐州医学院第二附属医院基金课题(Y2013038)

摘　　要：目的系统评价重症监护病房(ICU)患者使用氯己定洗浴预防中心静脉导管相关性血流感染(CRBSI)的效果。方法采取荟萃分析的方法,对ICU患者实施氯己定洗浴预防CRBSI的随机对照试验进行分析。结果干预组中心静脉总置管日59 963d,CRBSI感染86例;对照组总置管日61 804d,CRBSI感染251例,荟萃分析结果显示,氯己定洗浴能显著降低CRBSI的发生率(P=0.009,95%CI=0.28～0.45)。结论氯己定洗浴可减少皮肤表面的暂居菌,显著降低CRBSI的发生率,并能抑制其生长,从而降低CRBSI的风险。OBJECTIVE To systematically assess the effect of chlorhexidine bathing （CHB） on prevention of catheter-related bloodstream infections （CRBSI） in patients of intensive care unit. METHODS The randomized and controlled trials were performed to assess the effect of CHB on prevention of CRBSI in ICU patients. RESULTS The total central venous catheter indwelling time was 59 963 days in the intervention group, 61 804 days in the control group; the CRBSI occurred in 86 cases of the intervention group, 251 cases in the control group, The meta-analysis of the randomized, controlled trials revealed that the CHB could significantly reduce the incidence of CRBSI （P= 0. 009,95% CI= O. 28~0.45）. CONCLUSION The CHB can reduce the temporarily colonized bacteria on skin surface and inhibit the bacterial growth so as to reduce the risk of CRBSI.

关 键 词：重症监护病房 导管相关性血流感染 氯己定洗浴 荟萃分析 

分 类 号：R181.32[医药卫生—流行病学]