VEGF及CD34在外阴白色病变组织中的表达  

Expression of VEGF and CD34 in vulvar white lesions

作　　者：王春燕[1] 张利群[1] 蔡知天[1] 李楷滨[1] 姚兰[1] 王宁[1] 

机构地区：[1]吉林大学第一医院妇产科

出　　处：《中国妇幼保健》2013年第30期5036-5038,共3页Maternal and Child Health Care of China

摘　　要：目的:研究外阴白色病变组织中血管内皮生长因子(VEGF)和人原始造血细胞抗原(CD34)的表达,从而进一步探讨外阴白色病变的发病机制。方法:应用免疫组化方法观察62例外阴白色病变(包括外阴鳞状上皮增生32例,外阴硬化性苔藓30例)组织中的VEGF、CD34表达情况,10例正常外阴皮肤组织作为对照。结果:外阴硬化性苔藓(LS组)的VEGF的表达和微血管数目(MVD值)均显著低于正常外阴皮肤组及外阴鳞状上皮增生(SH组),差异有统计学意义(P<0.05);SH组与正常外阴组织相比差异无统计学意义(P>0.05),VEGF的表达与MVD计数在LS中存在正相关。结论:外阴硬化性苔藓组织中VEGF表达减少,引起MVD值显著减少,可能是外阴硬化性苔藓的发病机制之一;外阴鳞状上皮增生组织中VEGF的表达和MVD值无明显改变,微血管结构功能障碍可能是外阴鳞状上皮增生的发病机制之一。Objective： To research the expression of VEGF and CD34 in vulvar white lesions and to discuss the pathogenesis of the vulvar white lesions. Methods ： Immunohistochemical method was used to obse^e the expressions of VEGF and CD34 in 62 patients with vul- var white lesions （including 32 cases of vulval squamous epithelial hyperplasia and 30 cases of vulval lichen sclerosis） , 10 cases with nor- mal vulval tissue were selected as control group. Results： The expression of VEGF and microvessel density （MVD） of lichen sclerosis of vulva was statistically significantly lower than that in normal vulva group （ P 〈 0. 05 ） and that in vulval squamous epithelial hyperplasia group, the difference was statistically significant （ P 〈 0. 05） . There were no statistically significant difference in the expression of VEGF and MVD between vulval squamous epithelial hyperplasia group and normal vulva group （ P 〉 0. 05 ） , VEGF expression and MVD count were positive correlated in LS. Conclusion ： The expression of VEGF in vulva lichen sclerosis tissue has decreased, which lead to the decreasing of MVD, this may be one of the pathogenesis of vulva lichen sclerosis ; the expression of VEGF and MVD in vulval squamous epithelial hy- perplasia tissue has no obvious change, microvascuIar structure dysfunction may be one of the pathogenesis of squamous epithelial hyperpla- sia.

关 键 词：外阴白色病变 血管内皮生长因子 人原始造血细胞抗原 

分 类 号：R711.72[医药卫生—妇产科学]