长效GnRHa预防卵巢子宫内膜异位症术后复发的疗效  

Study on efficacy of GnRHa in preventing postoperative recurrence of ovarian endometrioma

作　　者：袁明[1] 汪雯雯[1] 高玲[1] 栗妍[1] 李天[1] 王世宣[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科

出　　处：《中国妇幼保健》2013年第30期5052-5055,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金项目〔81000240〕;高等学校博士点科研基金〔200804870009〕

摘　　要：目的:探讨卵巢子宫内膜异位症保守手术后辅助促性腺激素释放激素激动剂(GnRHa)治疗对疾病预后的影响。方法:选择因卵巢子宫内膜异位症行保守手术治疗或保守手术联合术后GnRHa巩固治疗的患者293例,根据术后用药情况分为用药组163例和非用药组130例,于治疗后定期随访,观察两组患者治疗后痛经或慢性盆腔疼痛缓解及复发情况、术后受孕情况及术后疾病复发等指标。结果:用药组患者痛经及慢性盆腔痛的症状较之未用药组明显缓解,且疼痛复发率明显低于非用药组(P<0.05);用药组的术后妊娠率高于非用药组(P<0.05);但是对于降低复发风险,两组人群间无明显差异。结论:卵巢子宫内膜异位症术后辅助GnRHa巩固治疗可缓解疾病相关的疼痛症状,提高术后的妊娠率,但不能降低疾病复发风险。Objective： To investigate the effect of GnRHa on prognosis of ovarian endometriosis after laparoseopic excision. Methods： A total of 293 ovarian endometriosis patients confirmed pathologically were evaluated retrospectively. 163 patients treated with GnRHa after laparoscopic excision were selected as drug group, and 130 cases with no treatment after surgery were selected as non - drug group. The remission rate of relevant symptoms, pregnancy after surgery, recurrence rate of disease were compared between the two groups during periodical follow - up period. Results： The symptom alleviation rate was higher and pain recurrence rate was lower in drug group when comparing with non - drug group. In addition, treatment with GnRHa could induce pregnancy after surgery. However, recurrence rate of disease between the two groups showed no significant difference. Conclusion： Treatment with GnRHa after conservative laparoscopic surgery could improve disease -related pain symptoms and infertility, while no significant difference was observed when analyzed the recur- rence rate.

关 键 词：卵巢子宫内膜异位症 复发 促性腺激素释放激素激动剂 

分 类 号：R711.71[医药卫生—妇产科学]