N-甲基-N-异丙基胺基磺酰胺的合成  

The Synthesis of N-Methyl-N-isopropyl Sulfonamide

作　　者：汤阿萍[1] 廖道华[1] 牛纪凤[1] 解西军[1] 高倩[1] 李爱军[1] 陈立鹏[1] 

机构地区：[1]华东理工大学药学院,上海200237

出　　处：《农药》2013年第10期721-722,725,共3页Agrochemicals

摘　　要：[目的]旨在探索并优化出一条适合工业化生产N-甲基-N-异丙基胺基磺酰胺的工艺路线。[方法]氯磺酰异氰酸酯与甲酸水溶液反应得到氨基磺酰氯,然后与N-甲基-N-异丙基胺反应得到目标产物N-甲基-N-异丙基胺基磺酰胺。[结果]反应总收率为62.7%,产物与中间体经1H NMR、MS等进行了表征。[结论]该路线收率较高,操作简便,可作为工业生产路线。[Aims] This article aims to explore and optimize a reasonable synthesis route of N-methyl-N-isopropyl sulfonamide on industrial scale. [Methods] Amino sulfonyl chloride was synthesized from chloriosulfonyl isocyanate and aqueous formic acid, then reacted with N-methy-N-isopropyl amine to get the target product. [Results] The total yield was 62.7%. The products and intermediates were determined by H NMR and MS and so on. [Conclusions] The yield is improved and the process is simplified, which can be used in industry.

关 键 词：N-甲基-N-异丙基磺酰胺 苯嘧磺草胺 合成 

分 类 号：TQ457.2[化学工程—农药化工]