BIS监测氟马西尼在全麻催醒中的应用研究  

Clinical study of flumazenil used in making awake after intravenous anesthesia by propofol under bispectral index monitoring

作　　者：张瑞娜 徐胜[2] 

机构地区：[1]中信重机职工医院麻醉科 [2]中国人民解放军第96531部队后勤部卫生所

出　　处：《医药论坛杂志》2013年第10期16-18,共3页Journal of Medical Forum

摘　　要：目的通过脑电双频指数（BIS）监测，评价氟马西尼加快全麻患者术后苏醒的临床效果。方法80例在全凭静脉麻醉下行择期胸部手术的患者。随机分为两组：F组术后静注氟马西尼组；C组术后静注生理盐水。记录指标：给药前（T0）、给药后1（T1）、5（T2）、10（T3）、15（T4）、30min（T5）患者的BIS、MAP、HR、镇静评分、理解评分、清醒时问、拔出支气管导管时间。结果T2～T5时两组的BIS、MAP、HR、镇静评分、理解评分均高于Tn（P〈0．05）；T2～T5，时F组的各个指标明显高于C组（P〈0．05）；F组的清醒时间、拔出气管导管时间明显短于C组（P〈0．05）。结论在全凭静脉麻醉中，氟马西尼能够有效地提升BIS值，加快恢复患者的意识，明显缩短术后苏醒时间。Objective To evaluate the clinical effects of flumazenil reverses propofol in order to make awake after intra- venous anaesthesia under bispectral index monitoring. Methods Eighty patients who undergoing intravenous anesthesia by propofol were studied. They were randomized into two groups ： group C receiving normal saline （ n = 40 ） as the con- trol,while group F receiving flumazenil （ n = 40）. Change of BIS, HR, MAP, Ramsay score, Understand score were ob- served at pre - administration （ To ）, 1 （ T1 ） ,5 （ T2 ）, 10 （ T3 ）, 15 （ T4 ）, 30rain （ T5 ） after administration respectively, revi- ving time, the time of pulling out the endotracheal tube. Results BIS, HR, MAP, Ramsay score, Understand score of group F at T2 -T5 increased significantly compared with at To （P 〈0. 05 ）and with group C too（ P 〈0. 05） ; the time of reviving and pulling out the endotracheal tube of group C was longer than group F （ P 〈 O. 05 ）. Conclusion Flumazenil can effectively improve the value of BIS, meanwhile promote to revive from intravenous anaesthesia by propofol, shorten reviving time after operation.

关 键 词：脑电双频指数 氟马西尼 丙泊酚 催醒 

分 类 号：R971[医药卫生—药品]