冠心病血瘀证的基因及蛋白质组学研究进展  

Advances in blood stasis syndrome of coronary heart disease in genomics and proteomics research

作　　者：吴彩凤[1] 张颖[1] 刘欣[2] 殷惠军[1] 

机构地区：[1]中国中医科学院西苑医院心血管中心,北京100091 [2]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2013年第10期2994-2996,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然基金(No.81073086)~~

摘　　要：冠心病是多因素、多基因相关的疾病,而血瘀证是冠心病的重要中医证候。冠心病血瘀证的基因组及蛋白质组学研究,采用先进的基因芯片技术、双向电泳、液相色谱和生物质谱技术,从核酸及蛋白水平揭示了证候的实质,找到冠心病血瘀证特异性的差异基因和差异蛋白,并进一步对差异基因和蛋白进行功能研究,揭示其在冠心病血瘀证的证候演变中的作用,并有望成为活血化瘀中药的作用靶点。Coronary heart disease is associated with several factors and genes. Blood stasis is a predominant syndrome of coronary heart disease. The research of genomics and proteomics adopts gene chips, two-dimensional electrophoresis, liquid chromatograph and bio-mass spectrometry. The differential genes and distinct protein were found and the essence of syndromes was shown in genetic and protein levels. Further studies on the function of these differential genes and protein showed that they played a role in the progress of blood stasis in the coronary heart disease and they may be the targets for activating blood circulation herbs.

关 键 词：冠心病 血瘀证 基因组学 蛋白质组学 

分 类 号：R259[医药卫生—中西医结合]