清热化湿、活血泻浊法干预大鼠慢性肾功能衰竭进展的实验研究  

Study on method of clearing heat and removing dampness and promoting blood circulation purging turbid intervention in chronic renal failure progression

作　　者：李葆青[1] 邱模炎[1] 李楠[1] 焦强[1] 吴鋆[1] 栾洁[1] 王绍华[1] 张万强[1] 孙卫红[1] 王爱强[1] 王瑾[1] 

机构地区：[1]中国中医科学院望京医院,北京100102

出　　处：《中华中医药杂志》2013年第10期3040-3042,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨清热化湿、活血泻浊法对大鼠慢性肾功能衰竭进展的干预作用。方法:采用5/6肾切除法制作慢性肾衰大鼠模型,术后4周检测血肌酐(SCr)、尿素氮(BUN)、血磷(P)、血钙(Ca)、血红蛋白(Hb)、24h尿蛋白定量等指标,确认造模成功后,将存活的大鼠随机分为模型组、尿毒清组、经验方组,分别给予相应治疗,给药4周(术后8周)处死大鼠,检测上述指标。结果:经验方组SCr、BUN均低于模型组及尿毒清组,差异有统计学意义(P<0.05);经验方组24h尿蛋白定量低于模型组,差异有统计学意义(P<0.05),与尿毒清组比较,差异无统计学意义。结论:采用清热化湿、活血泻浊法的经验方能够有效延缓5/6肾切除大鼠肾功能衰竭的进展,降低SCr、BUN,其作用优于对照药物尿毒清颗粒,且能够减少尿蛋白的排泄。Objective： To investigate the intervention of clearing heat and removing dampness and removing promoting blood circulation purging turbid in chronic renal failure （CRF） progression. Methods： The 5/6 nephrectomy was performed on rats of model group. 4 weeks after surgery, the serum biochemistry assay （SCr, BUN, P, Ca, Hb） and 24-hours＇ urinary albumin were detected to confirm the model was successfully maked. Rats who survived from surgery were randomly divided into model group, Niaoduqing group, and experimental prescription group and were given corresponding treatment respectively. 4 weeks after treatment （8 weeks after surgery）, the rats would be killed, and the serum biochemistry assay （SCr, BUN, Ca, P, Hb） and 24-hours＇ urinary albumin be detected. Results： The levels of SCr and BUN in experimental prescription group were obviously lower than these in model group and Niaoduqing group, and the differences were statistically significant （P〈0.05）. The level of 24-hours＇ urinary albumin in experimental prescription group was obviously lower than that in model group, and the difference was statistically significant （P〈0.05）; and it was lower than in Niaoduqing group, but there was no statistically significant difference. Conclusion： The experiential prescription of method of clearing heat and removing dampness and promoting blood circulation purging turbid could effectively slow the progression of renal failure caused of 5/6 nephrectomy in CRF model rats, and reduce the level of SCr and BUN. The therapeutic effect was better than Niaoduqing particles. It could effectively decrease the secretion of urine protein of 5/6 nephrectomy in CRF model rats, but not sure the effect was better than Niaoduqing particles.

关 键 词：清热化湿 活血泻浊 大鼠 5 6肾切除 慢性肾功能衰竭 

分 类 号：R277.5[医药卫生—中医学]