急性肺损伤/急性呼吸窘迫综合征肺肠相关证候特征及其演变的临床调查  

Clinical investigation on characteristic and evolution of the related syndromes of lung and large intestine of ALI/ARDS

作　　者：刘恩顺[1] 孙增涛[1] 苏景深[1] 封继宏[1] 王强[1] 郑莉[2] 

机构地区：[1]天津中医药大学第二附属医院,天津300150 [2]天津中医药大学,天津300193

出　　处：《中华中医药杂志》2013年第10期3125-3127,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)(No.2009CB522702)~~

摘　　要：目的:观察急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)肺与大肠证候的演变及关联情况。方法:收集127例ALI/ARDS患者,于第1、3、7天观察记录四诊资料并判断肺与大肠证候类型,采用frequency和spearman相关方法分析数据。结果:①肺系证候以痰热壅盛、肺热炽盛和肺气虚为主,其中痰热壅盛逐渐减少、肺气虚逐渐增加;大肠证候以肠热腑实、肠燥津亏和肠道气滞为主,其中肠燥津亏逐渐减少,肠道气滞始终无明显变化;②痰热壅盛与肠热腑实呈正相关;肺气虚与肠燥津亏和肠道气滞呈正相关,与肠热腑实呈负相关;肺热炽盛与肠道气滞呈正相关;肺阴虚与肠燥津亏呈正相关。结论:肺肠相关在ALI/ARDS临床证候中具有特定的表现形式并随病情发展呈现一定的演变规律,研究结果对深入了解该病病机特征及指导临床具有现实意义。Objective： To investigate the specific forms and evolution on the syndromes of correspondence between lung and large intestine in acute lung injury/acute respiratory distress syndrom （ALI/ARDS）. Methods： 127 ALI/ARDS patients were collected, recording data of the four methods of diagnosis on the first, the third and the seventh day to judge the syndrome types of the lung and large intestine, and to analyze data by methods of frequency distribution and spearman correlation. Results： ①Syndromes of phlegm and heat flourishing, lung heat thriving and lung-qi deficiency were major syndromes of lung disease, of which the syndrome phlegm and heat flourishing gradually reduced while lung-qi deficiency gradually increased; Syndromes of intestine heat accumulation, intestine-dryness fluid deficiency and intestine qi stagnation are major syndromes of large intestine disease, of which the syndrome of intestine-dryness fluid deficiency gradually decreased and intestine qi stagnation had no obvious change; ②Syndromes of phlegm and heat flourishing and intestine heat accumulation were positively correlated, syndromes of lung-qi deficiency and intestine-dryness fluid deficiency, intestine qi stagnation were positively, while lung-qi deficiency and intestine heat accumulation were negatively correlated; Syndromes of phlegm and heat flourishing and intestine qi stagnation were positively correlated; Syndromes of lung-yin deficiency and intestine-dryness fluid deficiency are negatively correlated. Conclusion： Correspondence between lung and large intestine in ALI/ARDS clinical syndromes has specific forms and some kinds of evolution rule with the illness development, which has realistic meanings in understanding the disease pathogenesis characteristics and clinical guidance.

关 键 词：急性肺损伤 急性呼吸穷迫综合征 肺与大肠相表里 肺肠相关 证候特征 调查研究 

分 类 号：R259[医药卫生—中西医结合]