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作 者:齐铮[1] 赵进喜[1] 周鑫[1] 谢莹[2] 庞博[3]
机构地区:[1]北京中医药大学第一临床医学院,北京100700 [2]长春中医药大学附属医院二部内分泌科,吉林长春130031 [3]中国中医科学院广安门医院,北京100053
出 处:《中华中医药学刊》2013年第10期2132-2135,共4页Chinese Archives of Traditional Chinese Medicine
基 金:国家十二五"重大新药创制"科技重大专项资助项目(2011ZX09302-006-01)
摘 要:目的:对糖尿病肾病辨证方案专家问卷进行分析,为中药新药治疗糖尿病肾病临床试验辨证方案提供规范化指导依据。方法:在文献调研基础上,编制糖尿病肾病辨证方案专家问卷,遵循德尔菲法原则,对中国内地、香港、新加坡26名专家进行问卷调查,对问卷进行回收、统计分析。结果:糖尿病肾病各期,常见主要证候、脏腑定位、基本证型的各条目,变异系数均<0.5。结论:气虚证、阴虚证、血瘀证、湿浊证在糖尿病肾病中占有较大比率;病变以肾、脾为中心,涉及肺、胃、肝、心等多个脏腑;气阴虚血瘀证、阳气虚血瘀证、阴阳俱虚血瘀证、阴阳俱虚血瘀湿浊证为糖尿病肾病的基本证型。Objective:To analyze the experts' opinions on principles of syndrome differentiation about diabetic nephropathy and to provide a standardized basis for guiding the Chinese medicine clinical trials of new drugs. Methods : Based on retrieving the literatures, the questionnaire was designed and a questionnaire survey of 26 experts from the Chinese mainland, Hong Kong and Singapore was conducted. Then, the statistical data was analyzed. Results : In every period of diabet- ic nephropathy, the coefficients of variation on common syndrome, organs positioning and types of syndrome were all less than 0.5. Conclusions : Syndromes of Qi deficiency, yin deficiency, blood stasis and turbid damp accounted for a large per- centage. Kidney and spleen were the main diseased regions, involving lung, stomach, liver, heart, and other organs ; Qi - yin deficiency and blood stasis, yang - Qi deficiency and blood stasis, yin - yang deficiency and blood stasis, yin - yang deficiency and blood stasis - turbid damp were the basic syndrome types of diabetic nephropathy.
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