夏季气温突变对胸痹大鼠心肌损害的实验研究  

Experimental Study of Myocardial Damage in Hypertensive Rats Induced by Sudden Rising and Dropping of Temperature in Summer

作　　者：罗颂明[1] 郭霞珍[1] 刘晓燕[2] 

机构地区：[1]福建中医药大学,福建福州350108 [2]北京中医药大学基础医学院,北京100029

出　　处：《中华中医药学刊》2013年第10期2292-2294,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：北京中医药大学自主选题项目(JYBZZ-JS020)

摘　　要：目的:探索夏季气温突变对胸痹大鼠心肌损害的影响。方法:给予肾动脉半结扎大鼠1次维生素D370 U/kg体重腹腔注射,22℃环境下饲以高脂饲料。10周后,予以升、降温处理。结果:气温骤升组大鼠急性心梗发病率为59.09%,气温骤降组大鼠发病率为26.32%,对照组发病率为28.57%,气温骤降组大鼠以及气温骤升组大鼠血清肌钙蛋白、肌酸激酶、谷草转氨酶、肌酸激酶同工酶、乳酸脱氢酶含量(P<0.05)均明显高于对照组大鼠,气温骤升组与气温骤降组大鼠肌钙蛋白等含量(P>0.1)无显著差异。结论:夏季气温骤升、骤降均能加重造成心肌损害。Objective ： To explore the experimental study of myocardial damage in hypertensive rats induced by sudden rising and dropping of temperature in summer. Methods ： Renal artery half ligated rats were treated with one intramuscular intraperitoneal injection of vitamin D3 （70 U/kg） followed by high cholesterol diet in 22 ℃. After 10 weeks,rats were in- duced by sudden rising and dropping of temperature. Results：The incidence of the temperature rising group was 59.09% , of the temperature dropping group was 26.32%, and of the control group was 28.57%. The contents of Troponin, Creatine Kinase, creatine Kinase - MB, Aspartate aminotransferase and Lactate dehydrogenase in the rising and dropping of temperature groups was higher than those in the control group（ P 〈 0. 05 ）. And the content had no significant differences between the rising and the dropping of temperature groups （P 〉 0.1 ）. Conclnsions：The rising and dropping of temperature can create myocardial damage.

关 键 词：胸痹 心肌损害 大鼠 

分 类 号：R473.71[医药卫生—护理学]