血浆载脂蛋白B/A1比值与颈总动脉内中膜厚度的关系  

The Relationship Between Serum ApoB/A1 Ration and Common Carotid Artery Intima-media Thickness in Patients With Stable Coronary Artery Disease

作　　者：石增刚[1] 张亮[1] 桑更生[1] 何佰生[1] 

机构地区：[1]蚌埠市第三人民医院心血管内科,安徽蚌埠233000

出　　处：《内蒙古医学杂志》2013年第7期773-775,共3页Inner Mongolia Medical Journal

摘　　要：目的:探讨血浆载脂蛋白B/A1比值(ApoB/A1 ratio)与颈动脉中膜厚度(IMT)的关系。方法:对于100例稳定型冠心病病人,应用彩色多普勒超声测定IMT,同时测定血浆载脂蛋白B(ApoB)、载脂蛋白A1(ApoA1)。阿托伐他汀(20 mg,1次/晚)治疗6个月后,重复上述检测。分析ApoB,ApoA1及ApoB/A1比值与IMT的相关性。结果:ApoB/A1比值与IMT呈明显正相关(r=0.53,P<0.01);6个月治疗后ApoB/A1比值的变化与IMT的变化亦呈明显正相关(r=0.50.P<0.01)。结论:ApoB/A1比值与动脉粥样硬化(AS)密切相关,可能反映了AS的程度。Objective： To investigate the relationship between serum ApoB/A1 ration and common carotid intima- media thickness（IMT）. Methods： In one hundred patients with stable coronary artery disease, thecarotid IMT were measured by Color Doppler flowing imaging, and serum ApoB, ApoA1 levels also measured at some time; after six- month lowering- lipid treatment （atorvastatin 20 mg qN）, above indexes were measured repeatly. Correlation analysis were applied to find the correlation between ApoB/A1 ration and the carotid IMT. is significantly correlative with carotid IMT, maybe reflect the severity of atherosclerosis （AS）. Results：A posi- tive correlation was found between ApoB/A1 ration （r = 0.53, p 〈 0.0l）and carotid IMT; After six - month lowering - lipid treatment, a positive correlatio was also found between △ApoB/A1 ration（ r = 0.50, P 〈 0.01 ） and △ IMT. Conclusion：The serun ApoB/A1 ration are significantly correlation with carotid IMT; It maybe re- flect the severity of atheroscleros（AS）.

关 键 词：血浆载脂蛋白B 血浆载脂蛋白A1 动脉内中膜厚度 

分 类 号：R392[医药卫生—免疫学]