α-,β-雌激素受体和孕激素受体在女性腺性膀胱炎中的表达及其意义  

Expression of α-,β- Strogen Receptor and Progestogen Receptor in Cystitis Glandularis and Their Clinical Significance

作　　者：佘绍逸[1] 郑晓[2] 李彤[1] 佘璇瑜[1] 何学军[1] 林明恩[1] 

机构地区：[1]汕头大学医学院第一附属医院泌尿外科,广东汕头515041 [2]汕头大学医学院学生工作部,广东汕头515041

出　　处：《汕头大学医学院学报》2013年第3期151-153,162,F0003,共5页Journal of Shantou University Medical College

基　　金：广东省医学科研基金立项课题(B2013267);汕头市科技计划资助项目(2011-46)

摘　　要：目的:探讨α-、β-雌激素受体(α、β-ER)、孕激素受体(PR)在腺性膀胱炎中的蛋白和mRNA表达水平及其临床意义。方法:采用免疫组化SP和实时荧光PCR法检测腺性膀胱炎(57例)和正常膀胱(15例)黏膜组织中α、β-ER、PR的表达。结果:α-ER在腺性膀胱炎的膀胱三角区及膀胱底部中的蛋白与mRNA的表达均明显低于正常对照,而β-ER、PR在2个部位的表达均与正常对照无统计学意义。结论:α-ER的表达下调可能参与了腺性膀胱炎的病理形成。Objectives. To investigate the expression and significance of a-, β-strogen receptor （a-, β-ER） and progestogen receptor （PR）in cystitis glandularis. Methods： The expression of a-, β-ER and PR was detected by immunohistochemical and quantitative PCR technique in 57 cases of cystitis glandularis and 15 cases of normal bladder. Results： The expression rate of β-ER was significantly higher than that of normal bladder mucosa tissue. The expression rate of β-ER and PR had no difference between two groups oftrigone zone and bladder fundus. Conclusion： The down-regulation expression ofa-ER in bladder mucosa tissue may be related to the biological behavior of cystitis glandularis.

关 键 词：腺性膀胱炎 α-雌激素受体 β-雌激素受体 孕激素受体 免疫组织化学 

分 类 号：R694[医药卫生—泌尿科学]