ARL15单核苷酸多态性与2型糖尿病合并大血管病变相关性研究现状  

Recent research on the ARL15 single nucleotide polymorphisms associated with macroanglopathy in type 2 diabetes

作　　者：曹玲[1,2] 崔正伟[1] 杨康鹃[1] 

机构地区：[1]延边大学医学院细胞生物学与医学遗传学教研室,延吉133002 [2]延边大学临床医学专业本科生2011级

出　　处：《国际遗传学杂志》2013年第5期220-223,共4页International Journal of Genetics

基　　金：国家自然基金资助项目（31060154）

摘　　要：ADP-核糖基化样因子15（ADP-ribosylation factor—like15，ARLl5）是ADP．核糖基化因子（ADP—ribosylationfactor，ARF）的亚家族成员之一。ARF是Ras超家族的小G蛋白。ARL与ARF成员之间有40％-60％的序列同源性。ARL广泛地存在于真核生物中，它们的种间序列保守性很高，在细胞内物质运输和信号转导过程具有重要作用。与ARF家族的其他成员相比，ARL不能作为霍乱毒的辅助因子、不能挽救ARFl和ARF2基因敲除发面酵母、不能直接激活磷酸酯酶D。最新研究发现ARL15的单核苷酸多态（single nucleotide polymor—phism，SNP）rs4311394的等位基因G与脂联素水平、2型糖尿病、胰岛素水平、胰岛素抵抗相关。该文通过对ARLl5基因的生物学特性、功能、以及该基因SNPs与2型糖尿病的相关性进行综述。ADP- ribosylation - like factor 15 （ ADP - ribosylation factor- like 15, ARL 15 ） is one of the members of ADP-ribosylation factor （ ADP-ribosylation factor, ARF ） subfamily. ARF is a small G protein of Ras superfamily. ARL has 40% - 60% homologous sequences with the members of ARF. ARL exists widely in eukaryotes, their sequence is very conservative. It plays an important role in intra- cellular material transport and signal transduction. Compared with the other members of the ARF family, ARL can not serve as a cofactor of the cholera toxin, can not save ARF1 and ARF2 knockout baker＇ s yeast, and can not directly activate phosphatase D. Recent studies have found that ARL 15 single nucleo- tide polymorphism （SNP）. rs4311394 allele G is related with adiponectin levels, type 2 diabetes, insu- lin levels and insulin resistance. This article reviews the biological characteristics and functions of ARL15 gene, and the association between its SNPs and type 2 diabetes mellitus.

关 键 词：ADP 核糖基化因子15 2型糖尿病 单核苷酸多态性 

分 类 号：R587.1[医药卫生—内分泌]