用T形微反应器制备10-羟基喜树碱-癸二酸-类水滑石纳米杂化物及性能研究  

Synthesis and properties of 10-hydroxyl camptothecin-sebacateLDH nanohybrids using T-type microchannel reactor

作　　者：庞秀江[1] 马秀明[1] 侯万国[2] 

机构地区：[1]青岛科技大学化学与分子工程学院,教育部生态化工重点实验室,山东青岛266042 [2]山东大学胶体与界面化学教育部重点实验室,山东济南250100

出　　处：《化学研究与应用》2013年第10期1357-1363,共7页Chemical Research and Application

基　　金：国家自然科学基金项目(No.21173135)资助;高等学校博士学科点专项科研基金项目(20110131130008)资助;山东省泰山学者基金项目(ts20070713)资助

摘　　要：通过二次组装法制备了粒径分布均匀的10-羟基喜树碱-癸二酸-LDH纳米杂化物(HCPT-SC-LDH)。首先利用T形微通道反应器,通过共沉淀法方法制备癸二酸柱撑的类水滑石(SC-HCPT),然后采用二次组装法制备HCPT-SC-LDH纳米杂化物。依据癸二酸和10-羟基喜树碱的分子尺寸和纳米杂化物的通道高度,推测癸二酸根可能以长轴垂直排列于LDH层间,药物通过疏水作用力进入层间。制备的样品粒径约为20-30nm,药物插层前后,颗粒的形貌也没有发生明显改变;当制备条件为老化温度30℃、老化时间3h,具有明显的药物缓释效果,其释放动力学过程符合准二级动力学方程。另外,所制备的纳米杂化物既可稳定HCPT的内酯环,又可明显提高HCPT的溶解度,是一种潜在的药物输送系统。The nanohybrid of 10-hydroxyl camptothecin（HCPT） intercalated layered double hydroxide（LDH） with narrow size distri bution was prepared by a secondary intercalation method. First, the nanohybrid of sebacate（SC） intercalated LDH was prepared u sing a T-type microchannel reactor via a co-precipitation method; and then HCPT was intercalated into the LDH＇ s gallery via hydro phobic interaction in ethanol medium. The parallel alkyl chains of perpendicularly arranged sebacate anions in the gallery provided a l＇/ydrophobic space for the drug intercalation. The so-obtained particle was uniform with size of 20-30nm and the morphology had no obvious change before and after drug intercalation. The drug-LDH nanohybrids that aged at 30℃ for 3 hours demofistrated obvi ous controlled release and the release in vitro of HCPT could be fitted with the pseudo-second-order model. Moreover, the encapsula ted HCPT could keep biologically active lactone structure, and the nanohybrid could improve the HCPT solubility. The nanocompos ites could be considered as a potential drug delivery system.

关 键 词：微通道反应器 10-羟基喜树碱 层状双金属氢氧化合物 癸二酸 缓释 

分 类 号：O641.1[理学—物理化学]