替米沙坦对原发性高血压患者炎症因子的影响  

Influence of telmisartan on inflammatory factors in patients with essential hypertension

作　　者：邓东波[1] 袁斌[1] 向磊[1] 

机构地区：[1]湖北省荆州市第二人民医院心内科,湖北荆州434000

出　　处：《心血管康复医学杂志》2013年第5期503-505,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察替米沙坦对原发性高血压患者炎症因子肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和高敏C反应蛋白(hsCRP)的影响。方法:64例原发性高血压患者采用随机数字表法分为替米沙坦组(32例)和硝苯地平组(32例),治疗12周,于治疗前后分别检测患者血压和血清TNF-α、IL-6及hsCRP含量。结果:治疗后,替米沙坦组血压及血清TNF-α、IL-6和hsCRP水平均较治疗前显著降低(P均<0.05),硝苯地平组除血压显著下降外,其余指标无明显变化;与硝苯地平组比较,治疗后替米沙坦组收缩压[(138.3±12.5)mmHg比(129.6±11.4)mmHg]、血清TNF-α[(12.43±3.72)ng/L比(7.36±2.81)ng/L]、IL-6[(26.82±7.12)ng/L比(18.15±6.64)ng/L]和hsCRP[(8.06±1.68)mg/L比(5.83±1.09)mg/L]水平降低更显著(P均<0.05)。结论:替米沙坦能够降低原发性高血压患者炎症因子肿瘤坏死因子α、白细胞介素6和高敏C反应蛋白水平,降低炎症反应,从而有益于血压的控制。Objective： To observe influence of telmisartan on levels of tumor necrosis factor α （TNF- α）, interleukin - 6 （IL - 6） and high sensitive C reactive protein （hsCR P） in patients with essential hypertension （EH）. Methods： A total of 64 EH patients were divided into telmisartan group （n = 32） and nifedipine group （n = 32） according to random digits table. All patients were treated for 12 weeks. Blood pressure, serum concentrations of TNF- α, IL- 6 and hsCRP were measured in both groups before and after treatment. Results： Compared with before treatment, there were significant decrease in blood pressure and serum levels of TNF- α, IL - 6 and hsCRP in telmisartan group after treatment （P〈0.05 all） ; there was significant decrease in blood pressure and no significant changes for TNF- α and IL-6 in nifedipine group after treatment. Compared with nifedipine group after treatment, there were sig-nificant decrease in levels of systolic blood pressure [ （138. 3 ± 12.5） mmHg vs. （129.6 ± 11.4） mmHgT, serum TNF -α[（12.43±3.72） ng/Lvs. （7.36±2.81） ng/L], IL-6 [ （26.82±7.12） ng/Lvs. （18. 15±6.64） ng/L] and hsCRP [ （8.06 ± 1.68） mg/L vs. （5.83 ± 1.09） mg/L] in telmisartan group, P〈0.05 all. Conclusion： Telmisartan can decrease levels of tumor necrosis factor α, interleukin-6 and high sensitive C reactive protein, decrease inflam-matory reactions and then contribute to blood pressure control in patients with essential hypertension.

关 键 词：高血压 替米沙坦 肿瘤坏死因子Α 白细胞介素6 

分 类 号：R544.1[医药卫生—心血管疾病]