kiss-1在子宫内膜异位症及子宫腺肌症异位组织中的表达及意义  

Expression and clinical significance of kiss-1 in endometriosis and adenomyosis

作　　者：金海鸿[1] 单梅[1] 李秀荣[1] 杨丽娜[1] 周立群[1] 李颖智[1] 

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150036

出　　处：《中国实验诊断学》2013年第10期1837-1838,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨kiss-1在子宫内膜异位症及子宫腺肌症异位组织中的表达及其意义。方法采用免疫组化方法检测正常子宫内膜、子宫内膜异位症及子宫腺肌症异位组织中kiss-1表达差异。结果正常子宫内膜、子宫内膜异位症及子宫腺肌症异位组织中kiss-1的阳性表达率分别75%、35%、52.5%,kiss-1蛋白在异位症及腺肌症表达缺失率明显高于正常内膜(P<0.01)。结论 kiss-1蛋白在子宫内膜异位症及子宫腺肌症的低表达可能与侵袭、转移相关,检测kiss-1蛋白有助于治疗和预后判断。Objective To study the expression and clinical significance of kiss-1 in endometriosis and adenomyosis, Methods The expression of kiss-1 were examined in 40 cases of endometriosis and adenomyosis,20 cases of normal en- dometrium. Results In 40 cases of endometriosis and adenomyosis,the positive rate of kiss-1 were 75 % ,35% ,and 52. 5 %, respectively, there were significant difference in the positive rates of kiss-1 in endometriosis and adenomyosis （P〈 0.01）. Conclusion The expression of kiss-1 was positively related to the metastasis and prognosis of endometriosis and adenomyosis,kiss-1 is valuable to predicting prognosis and guiding therapy of endometriosis and adenomvosis.

关 键 词：子宫内膜异位症 子宫腺肌症 KISS-1 免疫组化 

分 类 号：R711.71[医药卫生—妇产科学]