血清FERHDL变化与冠心病相关性的临床研究  

The study on relationship of fractional esterification rate of high density lipoprotein cholesterol and coronary artery disease

作　　者：索晓霞[1] 崔家玉[1] 唐福爱[1] 

机构地区：[1]山东省滨州市人民医院心血管内科,256610

出　　处：《重庆医学》2013年第29期3500-3502,共3页Chongqing medicine

摘　　要：目的探讨分析高密度脂蛋白胆固醇酯化速率(FERHDL)与冠心病的关系及其具体应用价值。方法回顾性分析该院近3年进行冠状动脉造影的患者,依据冠状动脉造影的结果将286例患者分为冠心病组(n=196)与非冠心病组(对照组,n=90),冠心病组根据狭窄病变累及血管范围分为1支病变(单支病变组,n=73例)、2支病变(双支病变组,n=72)和3支及以上病变(多支病变组,n=51),分析FERHDL与冠心病的具体关系及相关性。结果冠心病组FERHDL明显高于对照组,差异具有统计学意义(P<0.05)。FERHDL随冠状动脉病变范围的增加而升高即在单支病变、双支病变、三支病变组间有升高趋势,组间比较差异有统计学意义(P<0.05)。FERHDL与低密度脂蛋白胆固醇b-C(LDLb-C)、三酰甘油(TG)、高密度脂蛋白胆固醇2C(HDL2-C)、高密度脂蛋白胆固醇C(HDL-C)存在显著的独立相关关系,即与LDLb-C(r=8.473,P=0.000)、TG(r=0.714,P=0.002)呈正相关,与HDL2-C(r=-0.692,P=0.024)、HDL-C(r=-0.829,P=0.008)呈负相关。结论 FERHDL随冠心病患者病情加重而增高。FERHDL的变化与HDL和LDL颗粒直径大小密切相关。Objective To assess the relationship between fractional esterification rate of high density lipoprotein cholesterol （FERHDL） and coronary artery disease .Methods The patients were underwent coronary angiography in this hospital in the last three years were collected ,according to the results of coronary angiography ,286 patients were divided into CHD group（n=196） and non-CHD group（control group ,n=90） .And according to the number of pathological coronary artery ,the patients with coronary heart disease were divided into single-vessel subgroup（n=73） ,double vessel lesion subgroup（n=72） ,three branch lesions subgroup （n=51） .The relationship between FERHDL and coronary artery disease were analyzed .Results The FERHDL of CHD group was significantly higher than that in the control group ,the difference was statistically significant （P〈0 .05） .It was a tendency that the FERHDL increased with coronary lesions increasing （P〈0 .05） .The FERHDL was significant independent correlated with the low density lipoprotein cholesterol b-C（LDLb-C） ,triglycerides（TG） ,high density lipoprotein cholesterol 2-C（HDL2-C） ,high density lipoprotein cholesterol C（HDL-C） .FERHDL was positively correlated with LDLb-C（r=8 .473 ,P=0 .000） ,TG（r=0 .714 ,P=0 .002） and negatively correlated with HDL2-C（r= -0 .692 ,P=0 .024）、HDL-C（r= -0 .829 ,P=0 .008） .Conclusion The value of FERHDL was significantly increased in CHD patients and correlated with the aggravation severity of the CHD .The change of FERHDL was significant correlated with particle size of HDL and LDL particle size .

关 键 词：冠心病 冠状动脉 造影 脂蛋白类 HDL 酯化 

分 类 号：R541.4[医药卫生—心血管疾病]