新生儿呼吸窘迫综合征高危因素893例分析  

Analysis the risk factors of 893 cases of neonatal respiratory distress syndrome

作　　者：曲雯雯[1,2] 范含笑[1] 谢露[1] 韩笑[1] 尹晓娟[1,2] 

机构地区：[1]北京军区总医院附属八一儿童医院新生儿重症监护病房,北京100700 [2]大连医科大学北京军区总医院临床学院,辽宁大连116044

出　　处：《中国儿童保健杂志》2013年第10期1071-1074,共4页Chinese Journal of Child Health Care

基　　金：国家自然科学基金资助项目(30871397)

摘　　要：目的探讨新生儿呼吸窘迫综合征(respiratory distress syndrome,RDS)发病的高危因素,为临床治疗提供参考依据。方法对2007年1月-2012年10月在八一儿童医院新生儿监护病房住院确诊为RDS的893例新生儿进行回顾性研究。根据胎龄分为足月儿组(148例)和早产儿组(745例),将两组的性别、胎龄、出生体重、分娩方式、窒息、胎盘异常、胎膜早破、宫内感染、胎粪吸入综合征、孕母糖尿病、孕母高血压指各标进行组内及组间比较。采用SPSS 19.0对数据进行统计分析。结果单因素方差分析显示男性、剖官产、宫内感染、宫内窘迫是足月儿RDS发生的高危因素,早产、胎膜早破、孕母高血压、出生窒息是早产儿RDS发病的高危因素,多因素Logistic回归分析提示,胎龄、分娩方式、出生体重、胎膜早破、出生窒息、孕母糖尿病、孕母高血压、宫内感染为RDS发病危险因素(P<0.05),各因素在RDS发生中作用的大小顺序依次为:剖宫产>孕母高血压>宫内感染>出生体重>孕母糖尿病>出生窒息(OR值分别为71.136、66.117、65.824、38.565、4.935、1.940)。结论 RDS的发生是多因素的,早产、剖宫产、宫内感染、窒息缺氧、孕母高血压、孕母糖尿病等与新生儿呼吸窘迫综合征的发生密切相关,临床应予以重视。Objective To investigate the high risk {actors of neonatal respiratory distress syndrome （RDS）. Methods A retrospective data analysis method,893 cases of RDS infants were chosen in the neonatal intensive care unit in Bayi Hospital from January 2007 to October 20]2. Depending on gestational age, they were divided into full-term children group （ 148 cases） and preterm children group （745 cases）. Compared the gender, gestational age, birth weight, mode of delivery, as- phyxia, placental problem, premature rupture of fetal membranes, intrauterine infection, meconium aspiration syndrome, ma- ternal diabetes,maternal hypertension within the group and between groups,the data were analyzed by SPSS 19.0. Results Single factor analysis indicated that male, cesarean section, intrauterine infection, intrauterine distress were associated with RDS in full-term infants. Premature birth,premature rupture of membranes, maternal hypertension, asphyxia were risk fac- tors of RDS in the preterm infants. Multivariate logistic regression analysis showed high risk factors and the role of various factors in the RDS disease occur in the size were cesarean section〉 intrauterine infection〉 maternal hypertension〉 birth weight〉 maternal diabetes〉 birth asphyxia（OR was for 71. 136,66. 117,65. 824,38. 565,4. 935,1. 940 respectively）. Conclusions Many high risk factors are associated with RDS,premature birth,cesarean delivery,intrauterine infection,birth asphyxia,maternal hypertension,maternal diabetes are closely associated with RDS. These clinical factors should be given more attention.

关 键 词：新生儿呼吸窘迫综合征 高危因素 LOGISTIC回归分析 

分 类 号：R722.1[医药卫生—儿科]