小动物活体成像技术在肿瘤研究中的应用  

In Vivo Imaging Technology of Small Animals Applied in Cancer Study

作　　者：杨丽华[1] 沈星凯[1] 符丹[1] 余玉春[1] 赵渊[1] 龚朝辉[1,2] 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]浙江省病理生理学技术研究重点实验室,浙江宁波315211

出　　处：《宁波大学学报（理工版）》2013年第4期115-118,共4页Journal of Ningbo University：Natural Science and Engineering Edition

基　　金：浙江省公益性技术应用研究计划(2012C37102);宁波市自然科学基金(2012A610193);宁波市科技创新团队(2011B82014);宁波大学研究生优秀学位论文培育基金(PY2012010);宁波大学SRIP项目;宁波大学王宽诚教育基金

摘　　要：活体成像技术可以在近无创条件下对活体组织或小动物体内的生物学行为进行成像跟踪,已被广泛应用于肿瘤研究中.它的优势在于非侵入性地连续动态检测活体内肿瘤的生长及转移和评价肿瘤治疗的疗效.与传统的检测方法相比,大大减少了动物的用量,符合"3R"原则.文中综述了小动物活体成像技术的成像模式、技术原理和路线及其在肿瘤生长、转移与治疗过程中的应用.In vivo imaging technology has been used to take images of biological behavior in the living tissues or small animals under the noninvasive conditions,which has been widely applied in caner research.It has great advantage of real-time in vivo detection of tumor growth,metastasis and evaluation of tumor therapy.Compared with the traditional detection methods,in vivo imaging greatly reduces the number of test animals,which is consistent with the principle of ＂3R＂.This paper reviews the imaging modes,technical principles and routes,and the applications of in vivo imaging technology in the field of tumor growth,metastasis and treatment process of small animals.

关 键 词：活体成像 生物发光 荧光 放射性同位素 X光 肿瘤 

分 类 号：Q95-331[生物学—动物学]