缺血性中风中医证型与血浆TXB_2及6-keto-PGF1α关系的研究  

Study of relationship between TXB_2 and 6-keto-PGF1α in TCM syndromes of patients with ischemic stroke

作　　者：廖慧玲[1] 盛丹[2] 王全[1] 周喜芬[1] 石含秀[1] 尹思源[3] 

机构地区：[1]泸州医学院方剂教研室,四川泸州646000 [2]泸州医学院中医诊断教研室,四川泸州646000 [3]泸州医学院研究生院,四川泸州646000

出　　处：《泸州医学院学报》2013年第5期432-435,共4页Journal of Luzhou Medical College

基　　金：四川省中医药管理局科研项目(编号:20040B05)

摘　　要：目的:通过探讨缺血性中风中医辨证分型与血浆TXB2及6-keto-PGF1α之间的关系,力图进一步揭示缺血性中风各证型的本质及演变规律,筛选出能反映中医证候客观化的敏感指标。方法:以泸州地区200名急性缺血性中风患者作为研究对象,辨证分型,分组进行对比研究。结果:缺血性中风患者TXB2和6-keto-PGF1α存在明显直线相关和回归关系。缺血性中风不同中医证型组TXB2与6-keto-PGF1α值均成明显直线相关和回归关系:风痰瘀血闭阻脉络组直线回归方程为Y(TXB2)=691.79+0.56X(6-keto-PGF1α),(R=0.417,P=0.003<0.01,回归方程成立);风痰上扰痰热腑实组直线回归方程为Y(TXB2)=401.51+0.58X(6-keto-PGF1α),(R=0.491,P=0.000<0.01,回归方程成立);气虚血瘀组直线回归方程为Y(TXB2)=150.10+1.11X(6-keto-PGF1α),(R=0.638,P=0.001<0.01,回归方程成立);阴虚风动组直线回归方程为Y(TXB2)=184.19+0.91X(6-ketoPGF1α),(R=0.638,P=0.000<0.01,回归方程成立)。结论:TXB2及6-keto-PGF1α可以作为缺血性中风中医证型的客观化指标之一。Objective： To investigate the relationship between of TCM syndromes oi ischemic stroke and en- dothelial cell secretory function, in a bid to reveal the nature and effective sensitive indicator of the TCM syn- drome types. Methods： 200 patients with acute ischemic stroke in Luzhou city were differentiated according to their symptoms and signes into 4 TCM syndrome types：wind-phlegm with blood stasis and vessel block syndrome （type A）,upward disturbance of wind-phlegm and excess phlegm and heat of fu-viscera syndrom（type B）,Qidefi- cient and blood stasis syndrome （type C） and Yin deficient and wind-activation syndrome （type D）, and compar- atively studied. Results： There were significant linear and regressive correlations between TXB2 and 6-keto- PGFlct in 4 types of iscbemic stroke syndrome.The regression equation in type A, B, C, D were Y （TXB2） = 691.79 ＋0.56 X （6-keto-PGF1 cx）, （R = 0.417, P = 0.003 〈0.01）, Y （TXB2） = 401.51 ＋0.58 X （6-keto-PGF1 or）, （R = 0.491, P = 0.000 〈0.01）, Y （TXB2） = 150.10 ＋1.11 X （6-keto-PGF1 （x）, （R = 0.638, P = 0.001〈 0.01）, and Y （TXB2） = 184.19 ＋0.91 X （6-keto-PGF1 ct）, （R = 0.638, P = 0.000 〈0.01,） respectively. Con- clusion： TXB2 and 6-keto-PGFlot can be used as the objective indicators for the differential TCM syndrome types of ischemic stroke.

关 键 词：缺血性中风 TXB2 6-KETO-PGF1Α 中医证型 

分 类 号：R255.2[医药卫生—中医内科学]