山楂消脂胶囊对非急性期冠心病患者颈动脉内-中膜厚度和斑块积分的影响  

The effect of Shanzha Xiaozhi capsule on intima-media thickness and plaques score of carotid artery in patients with non-acute phase coronary heart disease

作　　者：王文会[1] 赵华云[1] 陈伟强[1] 罗子幸[1] 余秀兰[1] 刘照宏[2] 梁彤[2] 

机构地区：[1]佛山市中医院心血管内科,广东佛山528000 [2]佛山市中医院超声中心,广东佛山528000

出　　处：《中国中西医结合急救杂志》2013年第5期266-269,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：广东省中医药管理局科研基金资助项目（20111063）

摘　　要：目的观察山楂消脂胶囊对非急性期冠心病痰瘀证患者颈动脉内-中膜厚度（IMT）和斑块积分的影响。方法本研究采用前瞻性研究方法，将符合诊断标准的102例非急性期冠心病痰瘀症患者按随机数字表法分为两组。对照组（50例）给予西药常规治疗；观察组（52例）在对照组基础上加用山楂消脂胶囊（主要成分为山楂、大黄）0.7 g，每日3次，疗程均为6个月。观察两组急性心脑血管事件的发生率，同时比较治疗前后两组患者颈动脉IMT和斑块积分，以及痰浊证和血瘀证积分的变化和不良反应。结果观察组急性心脑血管事件发生率较对照组明显降低（5.77%比20.00%，P＜0.05）；两组治疗后颈动脉IMT、斑块积分及痰浊证积分和血瘀证积分均较本组治疗前明显降低，且以观察组降低更显著〔颈动脉IMT（mm）：0.80±0.13比0.95±0.12，斑块积分（分）：1.35±0.65比1.75±0.88，痰浊证积分（分）：20.98±6.42比35.55±9.22，血瘀证积分（分）：23.23±5.12比28.95±6.38，P＜0.05或P＜0.01〕。观察组有2例出现腹痛，无其他明显不良反应。结论山楂消脂胶囊可能通过祛痰、化瘀作用，减轻颈动脉内中膜的厚度，降低斑块积分，从而稳定斑块，减少急性心脑血管事件的发生。Objective To investigate the effect of Shanzha Xiaozhi capslue on intima-media thickness（IMT） and plaques score of carotid artery in patients with non-acute phase coronary heart disease and traditional Chinese medicine（TCM）syndrome of phlegm and blood stasis. Methods A prospective study was conducted to carry out a research on 102 patients with non-acute phase coronary heart disease and TCM syndrome of phlegm and blood stasis. They were randomly divided into two groups：a control group（50 cases）treated with conventional western medicine alone and a observation group（52 cases）which was treated by both conventional western medicine and Shanzha Xiaozhi capslue（the main TCM ingredients：Shanzha,Dahuang）0.7 g,3 times a day,the therapeutic course being 6 months in both groups. The cardiocerebral vascular incidences of the two groups were observed,in the mean time,the carotid artery IMT and plagues score were registered,the scores of phlegm stagnation syndrome and blood-stasis syndrome were measured,adverse reaction was observed and compared in both groups before and after treatment. Results After treatment,the occurrence of major adverse acute cardiovascular and cerebrovascular events in observation group were reduced significantly compared with those in the control group（5.77%vs. 20.00%,P〈0.05）. The IMT and plaques score of carotid artery and the scores of phlegm stagnation syndrome and blood-stasis syndrome were all decreased obviously compared to those before treatment,and the effect was more remarkable in the treatment group〔IMT of carotid artery（mm）：0.80±0.13 vs. 0.95±0.12,the plaques score：1.35±0.65 vs. 1.75±0.88, phlegm syndrome score：20.98±6.42 vs. 35.55±9.22,blood-stasis syndrome score：23.23±5.12 vs. 28.95±6.38, P〈0.05 or P〈0.01〕. Abdominal pain appeared in 2 patients of observation group without other adverse reactions. Conclusion Shanzha Xiaozhi capsule can stabilize atherosclerotic plaque and reduce the occurrence of acute adverse cardiocerebral vascul

关 键 词：山楂消脂胶囊 非急性期冠心病 颈动脉内-中膜厚度 斑块积分 痰浊证 血瘀证 

分 类 号：R587.2[医药卫生—内分泌]