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作 者:鹿欣伦[1] 张雨梅[1] 胡成云[1] 崔卫波[1] 刘学[1] 周明荣[1]
出 处:《中国兽医学报》2013年第10期1595-1598,共4页Chinese Journal of Veterinary Science
基 金:农业部兽药残留专项资助项目;江苏高校优势学科建设工程资助项目
摘 要:6头干奶期奶牛采用交叉试验,进行氟佐隆单剂量皮下注射1.5和3.0mg/kg的药动学试验。高效液相色谱法(HPLC)测定血清中氟佐隆质量浓度,方法的检测限和定量限分别为0.005和0.01mg/L。氟佐隆单剂量皮下注射,血药浓度-时间数据符合一级吸收一室开放模型。1.5mg/kg皮下注射,t1/2kα(15.80±0.23)h,t1/2ke(55.42±1.62)h,T(peak)(46.17±3.98)h,AUC(8.21±0.18)mg/(L·h),C(max)(0.09±0.01)mg/L;3mg/kg皮下注射给药,t1/2kα(12.68±1.49)h,t1/2ke(56.55±4.19)h,T(peak)(45.56±1.60)h,AUC(8.37±0.09)mg/(L·h),C(max)(0.09±0.00)mg/L。结果表明不同剂量给药时血药浓度相当,主要药动学参数无显著差异,提示临床用药可以采取低剂量给药。The pharmacokinetics of fluazuron were carried through the six nonlactating Holstein cows administrated by 1. 5 mg/kg and 3 mg/kg subcutaneous injection respectively. A HPLC method was developed for determining the concentration of fluazuron in serum,the limit of detec- tion (LOD) was 0. 005 mg/L,the limit of quantification (LOQ) was 0.01 mg/L. The concentra- tion-time data of fluazuron in serum after single subcutaneous injection in cattle were fitted to a one-compartment open model with first-order absorption. The main pharmacokinetic parameters were as follows(15. 80±0. 23) h,tlj2ke(55. 42±1. 62) h,T(pk)(46.17±3.98) h,AUC (8.21 ±0.18) mg/(L h) ,C (0.09!0.01) mg/L at 1.5 mg/kg dose;t2ko(12.68±1.49) (56. 55±4. 19) h,(45.56±1.60) h,AUC (8. 37±0.09) mg/(L . h),C〈 (0.09±0.00) mg/L at 3.0 mg/kg dose. Results showed that the blood drug concentrations at different doses administra tion were quite and the main pharmacokinetic parameters appeared no significant difference,impl ying that the low dose of 1.5 mg/kg was used in clinical medicine.
分 类 号:S859.79[农业科学—临床兽医学]
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