酮病和健康奶牛血清中触珠蛋白和血清淀粉样蛋白A浓度的比较研究  

Comparative study of haptoglobin and serum amyloid A protein in the serum of healthy dairy cows and cows with ketosis

作　　者：郝景锋[1,2] 王建国[3] 朱晓岩[3] 杨文涛[3] 丁洪岩[3] 史晓霞[3] 宋玉祥[3] 邓清华[3] 赵晨旭[3] 刘兆喜[3] 王力[1] 赵权[1] 刘国文[3] 

机构地区：[1]吉林农业科技学院动物医学学院,吉林吉林132101 [2]吉林农业大学研究生院,吉林长春130118 [3]吉林大学畜牧兽医学院,吉林长春130062

出　　处：《中国兽医杂志》2013年第9期9-11,共3页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金资助项目(31072178;30600441);国家科技支撑计划子课题(2012BAD12B03-2)

摘　　要：血清中触珠蛋白(HP)和血清淀粉样蛋白A(SAA)浓度的变化与奶牛代谢性疾病(如酮病、脂肪肝等)密切相关。为了明确酮病奶牛和健康奶牛血清中触珠蛋白和血清淀粉样蛋白A浓度差异,本试验运用酶联免疫吸附试验(ELISA),分别测定了酮病和健康奶牛血清中触珠蛋白和血清淀粉样蛋白A浓度,结果显示,酮病奶牛血清中触珠蛋白浓度和SAA浓度极显著高于(P<0.01)健康奶牛。结果表明,酮病奶牛普遍存在炎症等病理过程,这一结果可为进一步阐明奶牛酮病的发病机制提供理论依据。Concentrations of haptoglobin （HP） and serum amyloid A （SAA） protein in serum are closely related to metabolic diseases （such as ketosis, fatty liver）. In order to understand the differences of haptoglobin and serum amyloid A protein in the serum of healthy dairy cows and cows with ketosis the concentrations Of haptoglobin and serum amyloid A protein in the serum were measured these dairy cows by enzyme-linked immunosorbent assay （ELISA）. The results showed that concentrations of haptoglobin and SAA were significantly higher （P%0.01） in cows with ketosis than that of controls. These results in- dicate that pathophysiological process such as inflammation is ubiquitous in dairy cows with ketosis.

关 键 词：酮病 触珠蛋白 血清淀粉样蛋白A 

分 类 号：Q512.7[生物学—生物化学]