In situ modifed screen printed and carbon paste ion selective electrodes for potentiometric determination of naphazoline hydrochloride in its formulation  

作　　者：Gehad G.Mohamed F.A.Nour El-Dien Eman Y.Z.Frag Marwa El-Badry Mohamed 

机构地区：[1]Chemistry Department, Faculty of Science, Cairo University

出　　处：《Journal of Pharmaceutical Analysis》2013年第5期367-375,共9页药物分析学报（英文版）

摘　　要：The construction and performance characteristics of new sensitive and selective in situ modified screen printed （ISPE） and carbon paste （ICPE） electrodes for determination of naphazoline hydrochloride （NPZ-HC1） have been developed. The electrodes under investigation show potentiometric response for NPZ-HC1 in the concentration range from 7.0 x 10-7 to 1.0 x 10-2 M at 25 ~C and the electrode response is independent of pH in the range of 3.1-7.9. These sensors have slope values of 59.7＋0.6 and 59.2＋0.2 mV decade-l with detection limit values of 5.6 ~ 10-7 and 5.9 x 10-7 M NPZ- HC1 using ISPE and ICPE, respectively. These electrodes show fast response time of 4-7 s and 5-8 s and exhibits lifetimes of 28 and 30 days for ISPE and ICPE, respectively. Selectivity for NPZ-HC1 with respect to a number of interfering materials was also investigated. It was found that there is no interference from the investigated inorganic cations, anions, sugars and other pharmaceutical excipients. The proposed sensors were applied for the determination of NPZ-HC1 in pharmaceutical formulation using the direct potentiometric method. It showed a mean average recovery of 100.2% and 102.6% for ISPE and ICPE, respectively. The obtained results using the proposed sensors were in good agreement with those obtained using the official method. The proposed sensors show significantly high selectivity, response time, accuracy, precision, limit of detection （LOD）and limit of quantification （LOQ） compared with other proposed methods.The construction and performance characteristics of new sensitive and selective in situ modified screen printed （ISPE） and carbon paste （ICPE） electrodes for determination of naphazoline hydrochloride （NPZ-HC1） have been developed. The electrodes under investigation show potentiometric response for NPZ-HC1 in the concentration range from 7.0 x 10-7 to 1.0 x 10-2 M at 25 ~C and the electrode response is independent of pH in the range of 3.1-7.9. These sensors have slope values of 59.7＋0.6 and 59.2＋0.2 mV decade-l with detection limit values of 5.6 ~ 10-7 and 5.9 x 10-7 M NPZ- HC1 using ISPE and ICPE, respectively. These electrodes show fast response time of 4-7 s and 5-8 s and exhibits lifetimes of 28 and 30 days for ISPE and ICPE, respectively. Selectivity for NPZ-HC1 with respect to a number of interfering materials was also investigated. It was found that there is no interference from the investigated inorganic cations, anions, sugars and other pharmaceutical excipients. The proposed sensors were applied for the determination of NPZ-HC1 in pharmaceutical formulation using the direct potentiometric method. It showed a mean average recovery of 100.2% and 102.6% for ISPE and ICPE, respectively. The obtained results using the proposed sensors were in good agreement with those obtained using the official method. The proposed sensors show significantly high selectivity, response time, accuracy, precision, limit of detection （LOD）and limit of quantification （LOQ） compared with other proposed methods.

关 键 词：ISPE and ICPE POTENTIOMETRY Naphazoline hydrochloride Eye drops 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.1[化学工程—制药化工]