羟苯磺酸钙在慢性移植肾肾病中的应用  

The application of calcium dobesilate in chronic allograft nephropathy

作　　者：夏菊梅 孟伟 张瑞 贺艳君 张辉 郑海燕 杨建萍 常帅 韩敏[3] 

机构地区：[1]解放军第四七四医院肾内科,乌鲁木齐830011 [2]解放军第二七三医院门诊部 [3]华中科技大学同济医院肾内科

出　　处：《临床肾脏病杂志》2013年第9期415-417,共3页Journal Of Clinical Nephrology

基　　金：国家自然科学基金项目（编号：81270770;30971372）

摘　　要：目的观察应用羟苯磺酸钙治疗慢性移植肾肾病的疗效。方法58例肾移植术后患者出现慢性移植肾肾病后，在调整原有环孢素或他克莫司联合麦考酚酯和肾上腺皮质激素三联免疫抑制治疗方案的基础上加用羟苯磺酸钙（每次0．5g，每日3次，随访12周）。随访观察2组治疗前、后血清肌酐、尿素氮和尿蛋白含量的变化及其不良反应。结果他克莫司组和环孢素组治疗后血清肌酐水平与治疗前比较均有明显下降（均P〈0．01）。他克莫司组和环孢素组24h尿蛋白定量治疗前、后的组内比较有统计学差异（均P〈0．01）。他克莫司组和环孢素组血清尿素氮水平治疗前、后的组内比较有统计学差异（均P〈0．01）。羟苯磺酸钙组治疗期间3例出现恶心、纳差，1例出现头痛，减量后均症状消失。结论加用羟苯磺酸钙可改善慢性移植肾肾病患者的移植肾的肾功能，明显降低尿蛋白。Objective To observe the curative effect of chronic allograft nephropathy after ap- plication of calcium dobesilate. Methods 58 cases of chronic allograft nephropathy （CAN） patients after renal transplantation, to adjust the original immunosuppressive therapy which cyclosporine or ta- crolimus combined mycophenolate mofetil and adrenocortical hormone,combined with calcium dobesil- ate （0. 5 g each time, three times a day, followed up for 12 weeks）. Follow-up observation of two groups before and after treatment, serum creatinine, blood urea nitrogen and urinary protein content changes and adverse reactions. Results Tacrolimus and cyclosporine after treatment, serum creatinine and 24 h urinary protein quantitative compared with before treatment were significantly decreased （all P〈0. 01）. Tacrolimus and cyclosporine group before and after treatment serum levels of urea nitrogen in comparison was statistically significant （P〈0. 05）. Calcium dobesilate group of 3 cases with nause- a, decreased appetite during treatment, 1 case have a headache, all symptoms disappeared after dose re- duction. Conclusions Combined with calcium dobesilate improve the renal graft function of CAN, de- crease urinary protein.

关 键 词：羟苯磺酸钙 肾移植 血尿素氮 

分 类 号：R699.2[医药卫生—泌尿科学]