出 处:《中华放射学杂志》2013年第10期912-916,共5页Chinese Journal of Radiology
基 金:江苏省自然科学基金资助项目(BK2009316);江苏省第七批六大人才高峰项目(WSW-122);江苏省医学重点人才资助项目(RC2011129)
摘 要:目的 评价双能量CT肺血管增强分析(Lung Vessels)软件对儿童肺栓塞的检出价值.方法 2010年4月到2011年6月共47例儿童(≤18岁)肾病综合征患者进行双能量CT肺动脉成像(CTPA).2名放射科医师分别以患者、肺叶及栓子数为单位,利用Lung Vessels软件记录肺栓塞的有无;以常规CTPA作为参照标准,计算Lung Vessels软件检测儿童肺栓塞的敏感度、特异度、阳性预测值及阴性预测值,并利用Kappa检验分别计算以患者、肺叶及栓子个数为单位时2名阅片者之间的一致性.结果 常规CTPA检出13例肺栓塞患者35个肺叶共51个栓子,本组儿童肾病综合征患者肺栓塞的阳性率为27.6%(13/47).以患者为分析单位,阅片者1和阅片者2分别利用Lung Vessels软件检出了25例及21例肺栓塞患者,敏感度、特异度、阳性预测值及阴性预测值分别为100.0%(13/13)、58.6% (17/29)、43.3% (13/30)、100.0% (17/17)及100.0%(13/13)、76.5% (21/29)、50.0%(13/26)、100.0% (21/21).以肺叶为单位时,阅片者1和阅片者2分别利用Lung Vessels软件检测出了74个及63个肺叶有栓子,敏感度、特异度、阳性预测值及阴性预测值分别为94.3%(33/35)、79.5% (159/200)、44.6%(33/74)、98.7%(159/161)及97.1%(34/36)、85.5% (171/200)、54.0%(34/63)、98.8% (171/173).以栓子个数为单位时,阅片者1和阅片者2分别利用Lung Vessels软件检测出了134和105个栓子,敏感度、特异度、阳性预测值及阴性预测值分别为96.1% (49/51)、64.9% (159/245)、36.3% (49/135)、98.7%(159/161)及94.1%(48/51)、75.0% (171/228)、45.7%(48/105)、98.3% (171/174);以患者、肺叶和栓子个数为分析单位,2名阅片者利用Lung Vessels软件检测肺栓塞的一致性好(Kappa值分别为0.828、0.859、0.695,P值均<0.01).结论 与常规CT肺动脉成像相比,双能量CT的Lung VObjective To evaluate the value of dual energy CT with Lung Vessels application in diagnosing pulmonary embolism (PE) of children.Methods Forty-seven patients with nephrotic syndrome and aged ≤ 18 years old (32 male,15 female,mean age 15 years) underwent dual-energy CT pulmonary angiography (CTPA).Two radiologists recorded the presence or absence of emboli and counted the clots on a per-patient and per-lobe basis with Lung Vessels,respectively.With conventional CTPA as reference standard,sensitivity,specificity,positive predictive value (PPV),negative predictive value (NPV) of Lung Vessels application to detect PE were computed for two readers.Inter-reader agreement was also calculated.Results Conventional CTPA detected 51 clots in 35 lung lobes in 13 patients,giving PE incidence was 27.6% (13/47) for this cohort.On a per-patient basis,readers 1 and 2 detected 25 and 21 patients with PE with Lung Vessels,corresponding to sensitivities,specificities,PPVs,and NPVs of 100.0% (13/13),58.6% (17/29),43.3% (13/30),100.0% (17/17) and 100.0% (13/13),76.5% (21/29),50.0% (13/26),100.0% (21/21),respectively.On a per-lung lobe basis,readers 1 and 2 detected 74 and 63 clots with Lung Vessels,respectively,corresponding to sensitivities,specificities,PPVs,and NPVs of 94.3% (33/35),79.5% (159/200),44.6% (33/74),98.7% (159/161) and 97.1% (34/36),85.5% (171/200),54.0% (34/63),98.8% (171/173),respectively.On a per-clot basis,134 and 105 clots were detected with Lung Vessels application,corresponding to sensitivities,specificities,PPVs,and NPVs for DECT of 96.1% (49/51),64.9% (159/245),36.3% (49/135),98.7% (159/161) and94.1% (48/51),75.0% (171/228),45.7% (48/105),98.3% (171/174)for readers 1 and 2,respectively.Excellent or good inter-reader agreement was observed on a per-patient,per-lobe and per-clot basis (Kappa =0.828,0.859,0.695 ; all P 〈 0.01).Conclusions Dual-energyCT with Lung Vessels application has
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